Available for orders over $20
recommended for:
Daily exosome leave-on visibly smooths and supports skin regeneration. Formulated with next-gen exosomes and enzymes, this lightweight, silky leave-on helps reawaken skin’s natural surface renewal process, improving natural regeneration by 86%.*
Exfoliating enzymes help clear away dull surface cells, revealing smoother, brighter skin. A regenerative exosome blend acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles. In an independent clinical study, fine lines and wrinkles were visibly diminished in 2 weeks.*
*Versus untreated skin. Based on in vitro testing.
**Results at 2 weeks, based on a reduction in visible signs of skin aging in an independent clinical study with 32 subjects, 2 applications/day.
Apply to clean skin. Allow to absorb, then follow with the rest of your skin care routine. Use twice daily.
Key Ingredients:
Pumpkin enzyme: Exfoliates to reveal brighter, smoother skin daily
Regenerative exosome blend: Acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles
Botanical blend with phyto glycogen + prickly pear: Visibly brightens and smooths
Bio-fermented acetyl glucosamine: Hydrates and provides antioxidant protection
Water/Aqua/Eau, Lactobacillus/Pumpkin Ferment Extract, Propanediol, Lactococcus Ferment Lysate, Ethoxydiglycol, Hydrolyzed Soy Protein, Acetyl Glucosamine, Hydroxyacetophenone, Lactic Acid, Hydrolyzed Opuntia Ficus-Indica Flower Extract, Helianthus Annuus (Sunflower) Seed Oil, Citrus Aurantium Bergamia (Bergamot) Fruit Oil, Citrus Limon (Lemon) Peel Oil, Citrus Aurantium Dulcis (Orange) Peel Oil, Salvia Sclarea (Clary) Oil, Pyrus Malus (Apple) Fruit Extract, Viola Odorata Leaf Extract, Acacia Senegal Gum Extract, Curcuma Longa (Turmeric) Root Extract, Mucor Miehei Extract, Lavandula Spica (Lavender) Flower/Leaf/Stem Extract, Rosmarinus Officinalis (Rosemary) Leaf Oil, Litsea Cubeba Fruit Oil, Camellia Japonica Flower Extract, Glycerin, Mentha Piperita (Peppermint) Oil, Butylene Glycol, Lactobacillus Ferment, Glycogen, Urea, Caprylyl Glycol, Phospholipids, Glucosamine HCl, Xanthan Gum, PEG-40 Hydrogenated Castor Oil, 1,2-Hexanediol, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Citric Acid, Polyacrylate Crosspolymer-6, Acacia Senegal Gum, Sodium Chloride, Sodium Citrate, Disodium EDTA, Sodium Benzoate, Potassium Sorbate, Limonene, Linalool, Citral.
Dermalogica is dedicated to maintaining the accuracy of the ingredient lists on this website. However, because ingredients are subject to change, we cannot guarantee that these lists are complete, up-to-date and/or error-free. For an accurate listing of ingredients in each product, please refer to your product packaging.
Materials: Bottle: Glass, Pump/cap: Mixed material, Carton: Paper
What’s Recyclable: The bottle of this Dermalogica product is fully recyclable. The paper used in this carton is recyclable and comes from FSC certified responsibly managed forests.
How to Recycle: Ensure bottle is as empty as possible and place in recycling bin. Dispose of pump and cap in waste bin. Place carton in its recycling bin.
Recycling is subject to local policies and facilities.
Phyto Nature E² is a regenerating daily leave-on formulated for aging skin. It’s ideal for anyone seeking anti-aging skincare or a skin renewing treatment to address fine lines, wrinkles, dullness, and uneven texture. Recommended for mature or prematurely-aging skin, those experiencing fine lines, wrinkles, and loss of firmness. This leave-on exfoliant supports natural surface renewal for smoother, brighter, and more youthful-looking skin.
Phyto Nature E² features a next-generation Regenerative Exosome Blend with plant-based exosomes that act in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles. Pumpkin Enzyme exfoliates to reveal brighter, smoother skin daily. The Botanical Blend with Phyto Glycogen + Prickly Pear brightens and smooths skin, while Bio-Fermented Acetyl Glucosamine hydrates and provides antioxidant protection.
This anti-aging leave-on accelerates skin regeneration, visibly reduces fine lines and wrinkles, and resurfaces skin to improve brightness, texture, and smoothness. Daily exfoliating enzymes clear away dull surface cells, and regenerative exosomes act in multiple layers to diminish fine lines and wrinkles in as little as two weeks**.
Improves natural skin regeneration by up to 86% versus untreated skin*.
Exosomes are microscopic vesicles that act as cell messengers, enhancing communication between skin cells. In skincare, exosomes help support natural skin regeneration and renewal. Phyto Nature E² uses plant-based exosomes to reinforce cellular renewal and surface resurfacing, making it one of the most advanced exosome skin care products for at-home face treatments.
Exosomes in Phyto Nature E² promote natural skin regeneration and cellular communication, helping improve fine lines, dullness, and uneven texture. Enzymes enhance the benefits with daily exfoliation and help maintain smoother, brighter, and more youthful-looking skin.
Phyto Nature E² has a silky, lightweight texture that absorbs quickly without leaving a greasy residue. Its smooth, nourishing, layerable texture makes it easy to use with other leave-ons or moisturizers while providing gentle, daily skin resurfacing.
Apply Phyto Nature E² to clean skin as the first step after cleansing. Allow it to absorb fully before applying moisturizer or serum. Use twice daily, morning and night, to maximize the benefits of this antiaging, skin-renewing leave-on.
Yes. Phyto Nature E² layers easily with other leave-ons, moisturizers, or treatments. Its lightweight, silky texture supports both exfoliation and skin regeneration while integrating seamlessly into any daily skincare routine.
Phyto Nature E² is formulated for daily exfoliation and anti-aging benefits. Those with sensitive skin should patch test first. The plant-based exosomes and gentle Pumpkin Enzyme work together to support skin renewing and resurfacing without irritation for most users.
Visible improvements in skin smoothness, brightness, and fine lines may appear within two weeks of twice-daily use. Continued use supports long-term skin regeneration, leaving skin softer, firmer, and more radiant over time.
Overall rating: 4.68 / 5 from 50 reviews.
This leave-on product visibly smooths and supports skin regeneration, improving natural renewal by 86%. It diminishes fine lines and wrinkles, and leaves skin looking youthful and healthy.
Review topics: ["size","results","feels","lines","skin","looks","consistency","difference","bottle","face","serum","sample","summer"].
"It was just a sample experience but the sample was generous and lasted a couple of days. Great product to use in hot , humid summer in New Orleans , non sticky ( I have a not very pleasant experience with stickiness of products with gel/ watery consistency) . Holds very nice under makeup and SPF ( no rolling ). Skin staying nice and smooth even in dry ac interior."
"I was very excited to try this product because I’ve always loved Dermalogica and have had great results with many of their products. While it’s a nice formula and feels good on the skin, I didn’t notice a significant difference after using it, especially compared to some of their other treatments that I absolutely love. For the price, I was expecting a bit more visible results. It’s still a good product, but personally I prefer some of the other products in their line."
"This line works for me, although other reviews from other customers show that it does not work for everyone. You also MUST combine it with other dermatologica products for it to work better. All my facial products are dermatologica only. I trust them with my facial skin care and do not mix them with other brands. Thank you Dermatologica! I am loyal to you since 2011 for all my facial needs and I am very happy with the results. A happy consumer!"
"This is a gift for me when I purchased it. Honestly, I haven't tried it yet, but I will definitely give it a shot! Right now, I’m using the cream and the eye-lifting. But I know because it’s phyto nature, it will definitely give you amazing looks while using it consistency. All bottles size will last longer."
"I received a trial size because I always order from dermalogica. Thought it was going to be pretty good like any of their other products but this one for some reason my face responds so well to. I always wake up looking younger really and glowing and for some reason it clears up my face too. Will definitely switch to this line when all my other dermalogica products runs out. Very expensive line but I think it will be worth it"
"LIGUID GOLD-IN A BOTTLE! MY REVIEW- is that I agree with everything said about this product mentioned by "ALL" the posted reviews. "ALL" 505 of them, but who's counting."
"This product is not for me. Dermalogica recommends using it twice a day, morning & night, but I’m in my mid-70’s & this product really dried out my face, in spite of using the Phyto Nature Oxygen Cream & the Dynamic Skin Recovery, both of which I love. I just don’t need 24/7 exfoliation. Older really mature skin is more delicate - I'd recommend this product for younger skin."
"I love the whole Phyto line. It makes my skin smooth. I got the travel size and very small bottle so I am not sure it works for the fine lines."
"Not sure it is doing anything. But it does goes on smooth and feels nice. Hoping it would offset the side effects (rednesses) of retinol and calm my skin. I likely need to use this product religiously for more than a month to see real results."
"I received a sample of this product when I last ordered. I have to say it feels great & has made a definite difference in my skin! I'll be purchasing the full size when I'm done doing my reviews :)"
renew + resurface
hydrates and combats skin aging
exfoliates, smooths, brightens
tightens, tones, sculpts
reduces fine lines and hydrates
treats and prevents body breakouts
Choose 4 minis on orders $120+. Choose 4 minis + receive a mini gua sha charm on orders $150+. Select minis in cart. Limit 1 mini per product. No code needed. Offer valid while supplies last on qualifying U.S. purchases made on dermalogica.com from 12:00am PST July 1, 2026 through 11:59pm PST July 7, 2026. May not be combined with any coupon, discount or special offer; or applied to previous purchases. Gifts are non-transferable, non-refundable, non-negotiable and cannot be exchanged, returned, or redeemed for cash or merchandise credit. We reserve the right to substitute gift offered with an item of equal or greater value. We reserve the right to modify, cancel and limit any promotion or offer. We reserve the right to make changes to these terms and conditions at any time and for any reason.
A current list of skin care products eligible for purchase with HSA or FSA funds is available on our designated eligibility page. For comprehensive information regarding HSA/FSA qualifications and permitted card usage, please refer to our HSA/FSA information page. Eligibility requirements may change, and we reserve the right to modify the list of qualifying products at any time without prior notice.
Receive free shipping on all orders $20+. No code needed. Offer valid on qualifying continental U.S. purchases made on dermalogica.com from 12:00am PST June 27, 2026 through 11:59pm PST July 7, 2026. Orders outside the continental U.S. will receive free expedited shipping. May not be combined with any coupon, discount or special offer; applied to previous purchases; or redeemed for cash or merchandise credit. We reserve the right to modify, cancel and limit any promotion or offer. We reserve the right to make changes to these terms and conditions at any time and for any reason.
Offer valid on orders $125+. The code to redeem this offer can be found in your sign-up confirmation email. Code must be entered on the cart page to apply. Limit 1 redemption per customer. May not be combined with any coupon, discount or special offer; or applied to previous purchases. Gifts are non-transferable, non-refundable, non-negotiable and cannot be exchanged, returned, or redeemed for cash or merchandise credit. We reserve the right to substitute gift offered with an item of equal or greater value. We reserve the right to modify, cancel and limit any promotion or offer. We reserve the right to make changes to these terms and conditions at any time and for any reason. By clicking SUBSCRIBE, I accept the privacy terms and give my consent to receive Dermalogica marketing e-mails at the e-mail provided. Consent is not a condition of any purchase. Message and data rates may apply. Message frequency varies.
Offer valid for on all subscription orders. Must be signed up to our rewards program at time of order. No code needed.
Select one free travel size product on orders $20+. Must select in cart page. No code needed. Offer valid on qualifying U.S. purchases made on dermalogica.com. Gifts are non-transferable, non-refundable, non-negotiable and cannot be exchanged, returned, or redeemed for cash or merchandise credit. We reserve the right to substitute gift offered with an item of equal or greater value.
