8 min read
Which serum should i use?
04/22/2025 / Last Edited 11/17/2025Choosing the right serum starts with understanding your skin’s needs. Different serums target concerns such as hydration, dark spots, fine lines, wrinkles, and sensitive skin. This guide highlights the best Dermalogica serums for each skin concern, from anti-aging and brightening to skin-strengthening solutions.
Best serum for sculpting and facial symmetry
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Powered by neuroscience and propelled by human touch, NeuroTouch Symmetry Serum is a lightweight facial oil formulated to visibly restore facial symmetry for more sculpted-looking skin.*
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Best serum for strength and barrier resilience
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If you’re looking for stronger, more resilient skin, Dynamic Skin Strengthening Serum is exactly what you need. This nourishing multidefense serum builds barrier resilience to help skin age stronger.
• Strengthens skin to resist signs of aging. |
Best night serum for hydration and radiance
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BioLumin-C Night Restore is an overnight serum that restores the skin’s moisture barrier for long-lasting radiance and hydration.
• Provides long-lasting brightness + immediate hydration. |
Best serum for collagen preservation
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Promote, protect, and preserve skin’s collagen today, so you have more for tomorrow: Pro-Collagen Banking Serum supports visibly plumper, more luminous skin and hydrates to help reduce the look of fine lines into the future.
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Best retinol serum for fine lines and wrinkles
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Dynamic Skin Retinol Serum is a high-dose, fast-acting multi-retinoid with booster technology that helps visibly reduce the 4 signs of skin aging in just 2 weeks.*
*Clinical results with 30 volunteers on reduction in appearance of wrinkles, pores, dark spots, and uneven texture in 2 weeks test.
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Best personalized serum for changing skin needs
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Skin care just got smarter: Smart Response Serum delivers what your skin needs, when and where it needs it. It delivers a personalized response every time, for healthier-looking skin over time.
• Helps maintain optimal hydration levels. • Brightens and helps reduce the appearance of dark spots. • Helps to soothe and reduce the appearance of redness. • Helps improve the look of fine lines and wrinkles. |
Best serum for long-lasting hydration
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Kick-start skin’s hydration cycle: Circular Hydration Serum immediately floods skin with hydration, replenishes from within, and helps prevent future hydration evaporation.
• Immediately hydrates to quench dehydrated skin. • Delivers long-lasting hydration to help prevent future dehydration. • Replenishes skin from within. |
Best firming serum for smoother, younger-looking skin
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Our top choice for wrinkles is Phyto Nature Firming Serum, which is actually two serums in one. It uses biomimetic peptides and potent botanicals to reawaken the nature of younger-looking skin.
• Doubles skin’s luminosity after just 1 application. • Minimizes the appearance of fine lines after just 1 application. • Reduces visible wrinkles in 4 weeks. |
Best brightening serum for dull or uneven skin
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That would be BioLumin-C Serum! This brightening Vitamin C serum outperforms the competition by delivering three times more Vitamin C to skin.
• Exfoliates and reduces unbalanced pigmentation. • Reduces the appearance of fine lines and wrinkles. • Prevents and corrects free radical damage. |
Best serum for acne and aging skin
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Clear breakouts and related signs of skin aging simultaneously by using a 2-in-1 solution like AGE Bright Clearing Serum.
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Overnight: Retinol Clearing Oil is a high-performance night oil that combines Retinol and Salicylic Acid into one skin-soothing formula that Exfoliates to help prevent breakouts and accelerate cell turnover.
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Best serum for hyperpigmentation
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Use PowerBright Dark Spot Serum, a potent hyperpigmentation-fading serum that starts fading the appearance of dark spots within days.
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Best serum for sensitive or redness-prone skin
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Our top choice is UltraCalming Serum Concentrate, the ultimate antidote for sensitive skin. This super concentrated gel is packed with skin soothing ingredients.
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What is a serum, anyway?
Skin care serums are topical treatments that target specific skin concerns. They are usually applied after cleansing and/or exfoliating, but before facial oils or moisturizers, for the best results.
Facial oils and moisturizers can create a protective barrier that prevents serums from absorbing into your skin surface, which is why serums should go on first. You can apply one serum or layer different serums on top of one another to treat different concerns.
How do I layer serums?
Apply your serums from lightest texture to heaviest texture. If you are unsure whether it is okay to layer your serums, ask a Dermalogica skin therapist.
Want to learn more about which skin care products are right for you? Visit your local Dermalogica skin therapist for a completely customized regimen.
Get more skin care tips at dermalogica.com
Want to learn more about which skin care products are right for you?
Visit your local Dermalogica skin therapist for a completely customized regimen.












