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recommended for:

mature or prematurely-aging skin
fine lines and wrinkles
loss of firmness and elasticity

Daily exosome leave-on visibly smooths and supports skin regeneration. Formulated with next-gen exosomes and enzymes, this lightweight, silky leave-on helps reawaken skin’s natural surface renewal process, improving natural regeneration by 86%.*

Exfoliating enzymes help clear away dull surface cells, revealing smoother, brighter skin. A regenerative exosome blend acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles. In an independent clinical study, fine lines and wrinkles were visibly diminished in 2 weeks.*

*Versus untreated skin. Based on in vitro testing.

**Results at 2 weeks, based on a reduction in visible signs of skin aging in an independent clinical study with 32 subjects, 2 applications/day.

benefits

Before and after skin improvement over one use and two weeks

Regenerative exosome blend helps diminish the appearance of fine lines + wrinkles
Accelerates skin's natural cellular renewal
Resurfaces to reveal brighter, smoother skin every day

how to use

Apply to clean skin. Allow to absorb, then follow with the rest of your skin care routine. Use twice daily.

ingredients

Key Ingredients:

Pumpkin enzyme: Exfoliates to reveal brighter, smoother skin daily
Regenerative exosome blend: Acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles
Botanical blend with phyto glycogen + prickly pear: Visibly brightens and smooths
Bio-fermented acetyl glucosamine: Hydrates and provides antioxidant protection

Water/Aqua/Eau, Lactobacillus/Pumpkin Ferment Extract, Propanediol, Lactococcus Ferment Lysate, Ethoxydiglycol, Hydrolyzed Soy Protein, Acetyl Glucosamine, Hydroxyacetophenone, Lactic Acid, Hydrolyzed Opuntia Ficus-Indica Flower Extract, Helianthus Annuus (Sunflower) Seed Oil, Citrus Aurantium Bergamia (Bergamot) Fruit Oil, Citrus Limon (Lemon) Peel Oil, Citrus Aurantium Dulcis (Orange) Peel Oil, Salvia Sclarea (Clary) Oil, Pyrus Malus (Apple) Fruit Extract, Viola Odorata Leaf Extract, Acacia Senegal Gum Extract, Curcuma Longa (Turmeric) Root Extract, Mucor Miehei Extract, Lavandula Spica (Lavender) Flower/Leaf/Stem Extract, Rosmarinus Officinalis (Rosemary) Leaf Oil, Litsea Cubeba Fruit Oil, Camellia Japonica Flower Extract, Glycerin, Mentha Piperita (Peppermint) Oil, Butylene Glycol, Lactobacillus Ferment, Glycogen, Urea, Caprylyl Glycol, Phospholipids, Glucosamine HCl, Xanthan Gum, PEG-40 Hydrogenated Castor Oil, 1,2-Hexanediol, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Citric Acid, Polyacrylate Crosspolymer-6, Acacia Senegal Gum, Sodium Chloride, Sodium Citrate, Disodium EDTA, Sodium Benzoate, Potassium Sorbate, Limonene, Linalool, Citral.

Dermalogica is dedicated to maintaining the accuracy of the ingredient lists on this website. However, because ingredients are subject to change, we cannot guarantee that these lists are complete, up-to-date and/or error-free. For an accurate listing of ingredients in each product, please refer to your product packaging.

sustainability

Materials: Bottle: Glass, Pump/cap: Mixed material, Carton: Paper

What’s Recyclable: The bottle of this Dermalogica product is fully recyclable. The paper used in this carton is recyclable and comes from FSC certified responsibly managed forests.

How to Recycle: Ensure bottle is as empty as possible and place in recycling bin. Dispose of pump and cap in waste bin. Place carton in its recycling bin.

_{Recycling is subject to local policies and facilities.}

Learn more about Dermalogica's sustainability efforts here.

FAQ

Who is this leave-on recommended for?

Phyto Nature E² is a regenerating daily leave-on formulated for aging skin. It’s ideal for anyone seeking anti-aging skincare or a skin renewing treatment to address fine lines, wrinkles, dullness, and uneven texture. Recommended for mature or prematurely-aging skin, those experiencing fine lines, wrinkles, and loss of firmness. This leave-on exfoliant supports natural surface renewal for smoother, brighter, and more youthful-looking skin.

What are the key active ingredients?

Phyto Nature E² features a next-generation Regenerative Exosome Blend with plant-based exosomes that act in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles. Pumpkin Enzyme exfoliates to reveal brighter, smoother skin daily. The Botanical Blend with Phyto Glycogen + Prickly Pear brightens and smooths skin, while Bio-Fermented Acetyl Glucosamine hydrates and provides antioxidant protection.

What benefits does it provide?

This anti-aging leave-on accelerates skin regeneration, visibly reduces fine lines and wrinkles, and resurfaces skin to improve brightness, texture, and smoothness. Daily exfoliating enzymes clear away dull surface cells, and regenerative exosomes act in multiple layers to diminish fine lines and wrinkles in as little as two weeks**.

Improves natural skin regeneration by up to 86% versus untreated skin*.

What are exosomes in skincare?

Exosomes are microscopic vesicles that act as cell messengers, enhancing communication between skin cells. In skincare, exosomes help support natural skin regeneration and renewal. Phyto Nature E² uses plant-based exosomes to reinforce cellular renewal and surface resurfacing, making it one of the most advanced exosome skin care products for at-home face treatments.

What do exosomes do for skin?

Exosomes in Phyto Nature E² promote natural skin regeneration and cellular communication, helping improve fine lines, dullness, and uneven texture. Enzymes enhance the benefits with daily exfoliation and help maintain smoother, brighter, and more youthful-looking skin.

What is the texture like?

Phyto Nature E² has a silky, lightweight texture that absorbs quickly without leaving a greasy residue. Its smooth, nourishing, layerable texture makes it easy to use with other leave-ons or moisturizers while providing gentle, daily skin resurfacing.

How do I use this leave-on?

Apply Phyto Nature E² to clean skin as the first step after cleansing. Allow it to absorb fully before applying moisturizer or serum. Use twice daily, morning and night, to maximize the benefits of this antiaging, skin-renewing leave-on.

Can I layer it with other products?

Yes. Phyto Nature E² layers easily with other leave-ons, moisturizers, or treatments. Its lightweight, silky texture supports both exfoliation and skin regeneration while integrating seamlessly into any daily skincare routine.

Is it suitable for sensitive skin?

Phyto Nature E² is formulated for daily exfoliation and anti-aging benefits. Those with sensitive skin should patch test first. The plant-based exosomes and gentle Pumpkin Enzyme work together to support skin renewing and resurfacing without irritation for most users.

When can I expect to notice differences?

Visible improvements in skin smoothness, brightness, and fine lines may appear within two weeks of twice-daily use. Continued use supports long-term skin regeneration, leaving skin softer, firmer, and more radiant over time.

phyto nature e² regenerating daily exosome leave-on treatment

renew + resurface

phyto nature e² regenerating daily exosome leave-on treatment

Price:

$158

or 4 payments of $39.50 with or

Select Size: 3.4 oz

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recommended for:

mature or prematurely-aging skin
fine lines and wrinkles
loss of firmness and elasticity

*Versus untreated skin. Based on in vitro testing.

**Results at 2 weeks, based on a reduction in visible signs of skin aging in an independent clinical study with 32 subjects, 2 applications/day.

Professional Treatment Pairing:

pro firm

firm + retexturizing treatment

FIND A PROFESSIONAL

View full details

benefits

Before and after skin improvement over one use and two weeks

Regenerative exosome blend helps diminish the appearance of fine lines + wrinkles
Accelerates skin's natural cellular renewal
Resurfaces to reveal brighter, smoother skin every day

how to use

Apply to clean skin. Allow to absorb, then follow with the rest of your skin care routine. Use twice daily.

ingredients

Key Ingredients:

Pumpkin enzyme: Exfoliates to reveal brighter, smoother skin daily
Regenerative exosome blend: Acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles
Botanical blend with phyto glycogen + prickly pear: Visibly brightens and smooths
Bio-fermented acetyl glucosamine: Hydrates and provides antioxidant protection

sustainability

Materials: Bottle: Glass, Pump/cap: Mixed material, Carton: Paper

What’s Recyclable: The bottle of this Dermalogica product is fully recyclable. The paper used in this carton is recyclable and comes from FSC certified responsibly managed forests.

How to Recycle: Ensure bottle is as empty as possible and place in recycling bin. Dispose of pump and cap in waste bin. Place carton in its recycling bin.

_{Recycling is subject to local policies and facilities.}

Learn more about Dermalogica's sustainability efforts here.

FAQ

Who is this leave-on recommended for?

What are the key active ingredients?

What benefits does it provide?

Improves natural skin regeneration by up to 86% versus untreated skin*.

What are exosomes in skincare?

What do exosomes do for skin?

What is the texture like?

How do I use this leave-on?

Can I layer it with other products?

Is it suitable for sensitive skin?

When can I expect to notice differences?

real skin, real results

Overall rating: 4.7996454 / 5 from 564 reviews.

AI Generated Review Summary

Phyto Nature e² is a lightweight, silky leave-on product that visibly smooths and supports skin regeneration. It is formulated with next-gen exosomes and enzymes to improve natural regeneration by 86%. Customers rave about its ability to make skin look fresher, brighter, and more awake, while also feeling silky and absorbing quickly without residue.

Summary topics

Product Texture: 39%
Skin Appearance: 34%
Skin Brightness and Smoothness: 67%
Application Feel: 34%
Absorption Speed: 29%

Review topics: [size, absorbs, results, issues, ingredients, irritation, improvement, works, wrinkles, weight, smell, use, quality, fragrance, feels, lines, texture, packaging, value, difference, formula, skin, looks, effect, glow, face, complexion, serum, bottle, residue].

Review highlights

"The texture feels silky but not heavy, and it absorbs fast without leaving any film." — Anna P.
"The texture feels silky and lightweight during application, and it absorbs quickly without any residue." — Nhi85
"It feels lightweight yet deeply nourishing, and my skin looks noticeably smoother and more lifted." — Mallory

Reviews

I absolutely love this product.

"I absolutely love this product. I’m 70 years old and have been using it for a month. My skin looks smoother. My pores are tighter. It is definitely making a positive difference."

— Jacalyn S. (5/5)

High hopes

"I’ve only been using the products for two weeks so I can’t really say that it’s a good thing. I’ve had to cut back to once a day as I have experienced stinging. That being said I have loved all Dermalogica for a long time and I have high hopes. At 74 years old my skin looks great and I give most of the credit to Dermalogica,"

— Joan M. (5/5)

As a 69 year old,

"As a 69 year old, and very concerned of looking fresh and hopefully a looking a little youthful for my age, ‘regenerating’ is essential for the price. Love the feel, the smell and the benefits!"

— Liza L. (5/5)

Less lines

"What a difference in my fine lines and dull skin after a week. Love this product."

— Lisa K. (5/5)

Hardly see improvements on my

"Hardly see improvements on my skin. Expecting something more from a product on an expensive side. Disappointed."

— AIDA C. (3/5)

Not What I Expected :/

"I have been using the Phyto Nature Regenerating Daily Formula as recommended (2x/day) for more than a month, and haven't seen any results."

— Jamaica G. (1/5)

Have definitely noticed a difference!

"I have noticed a difference in my skin since I've started using this - it really has made my skin become smoother and brighter and reduced some of my facial lines as well. I am purchasing my 2nd bottle and look forward to more improvement over time."

— JoS (5/5)

Exosome

"I really like this product. It feels light and absorbs quickly. It is helping to soften my fine lines."

— Jessy Y. (5/5)

I use this every morning.

"I use this every morning. It makes my skin look amazing."

— Heidi C. (5/5)

I have not seen the

"I have not seen the promised results Doubt I will purchase again"

— Lyne S. (3/5)

Q&A

Can I use this with the phyto firming serum?: Hello Kris, Thank you for choosing Dermalogica. You can use the Phyto nature firming serum as your serum step after you apply the phyto E2 for your regeneration and/or exfoliation step. We offer free skin consultations via chat with our professional skin experts on https://www.dermalogica.com/pages/contact-us. We also offer free video consultations. Here is a link to book a free 20 minute video consultation with one of our professional skin therapists! https://www.dermalogica.com/pages/video-consultations-page We look forward to speaking to you. Kind Regards, Melissa Dermalogica Professional Skin Therapist
is this product vegan friendly?: Yes, we are certified vegan by PETA on all current Dermalogica product formulas.
Does this have any fragrance in it??: Hello Jennifer, Thank you for reaching out to Dermalogica. I'm happy to say that Dermalogica products are free from artificial/synthetic fragrances and colors. Any scent is naturally occurring due to the botanicals used. Kind Regards Willow Dermalogica Professional Skin Therapist
Does it need to be stored in the refrigerator, since it contains exosomes?: Hello Mark, Thank you for choosing Dermalogica. No, the Phyto Nature E2 does not need to be stored in the refrigerator at this time. The formula has been carefully developed and tested to remain stable at normal room temperature. As long as the product is stored according to the recommended guidelines—away from direct sunlight and excessive heat—its quality and effectiveness will be maintained. Kind Regards, Melissa Dermalogica Professional Skin Therapist
Hello, can this be layered with the retinol cream at night?: Hello Alex, Thank you for reaching out to Dermalogica. Yes, you may apply this along with your dynamic skin retinol seurm Kind Regards Willow Dermalogica Professional Skin Therapist