recommended for:
Daily exosome leave-on visibly smooths and supports skin regeneration. Formulated with next-gen exosomes and enzymes, this lightweight, silky leave-on helps reawaken skin’s natural surface renewal process, improving natural regeneration by 86%.*
Exfoliating enzymes help clear away dull surface cells, revealing smoother, brighter skin. A regenerative exosome blend acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles. In an independent clinical study, fine lines and wrinkles were visibly diminished in 2 weeks.*
*Versus untreated skin. Based on in vitro testing.
**Results at 2 weeks, based on a reduction in visible signs of skin aging in an independent clinical study with 32 subjects, 2 applications/day.
Apply to clean skin. Allow to absorb, then follow with the rest of your skin care routine. Use twice daily.
Key Ingredients:
Pumpkin enzyme: Exfoliates to reveal brighter, smoother skin daily
Regenerative exosome blend: Acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles
Botanical blend with phyto glycogen + prickly pear: Visibly brightens and smooths
Bio-fermented acetyl glucosamine: Hydrates and provides antioxidant protection
Water/Aqua/Eau, Lactobacillus/Pumpkin Ferment Extract, Propanediol, Lactococcus Ferment Lysate, Ethoxydiglycol, Hydrolyzed Soy Protein, Acetyl Glucosamine, Hydroxyacetophenone, Lactic Acid, Hydrolyzed Opuntia Ficus-Indica Flower Extract, Helianthus Annuus (Sunflower) Seed Oil, Citrus Aurantium Bergamia (Bergamot) Fruit Oil, Citrus Limon (Lemon) Peel Oil, Citrus Aurantium Dulcis (Orange) Peel Oil, Salvia Sclarea (Clary) Oil, Pyrus Malus (Apple) Fruit Extract, Viola Odorata Leaf Extract, Acacia Senegal Gum Extract, Curcuma Longa (Turmeric) Root Extract, Mucor Miehei Extract, Lavandula Spica (Lavender) Flower/Leaf/Stem Extract, Rosmarinus Officinalis (Rosemary) Leaf Oil, Litsea Cubeba Fruit Oil, Camellia Japonica Flower Extract, Glycerin, Mentha Piperita (Peppermint) Oil, Butylene Glycol, Lactobacillus Ferment, Glycogen, Urea, Caprylyl Glycol, Phospholipids, Glucosamine HCl, Xanthan Gum, PEG-40 Hydrogenated Castor Oil, 1,2-Hexanediol, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Citric Acid, Polyacrylate Crosspolymer-6, Acacia Senegal Gum, Sodium Chloride, Sodium Citrate, Disodium EDTA, Sodium Benzoate, Potassium Sorbate, Limonene, Linalool, Citral.
Dermalogica is dedicated to maintaining the accuracy of the ingredient lists on this website. However, because ingredients are subject to change, we cannot guarantee that these lists are complete, up-to-date and/or error-free. For an accurate listing of ingredients in each product, please refer to your product packaging.
Materials: Bottle: Glass, Pump/cap: Mixed material, Carton: Paper
What’s Recyclable: The bottle of this Dermalogica product is fully recyclable. The paper used in this carton is recyclable and comes from FSC certified responsibly managed forests.
How to Recycle: Ensure bottle is as empty as possible and place in recycling bin. Dispose of pump and cap in waste bin. Place carton in its recycling bin.
Recycling is subject to local policies and facilities.
Phyto Nature E² is a regenerating daily leave-on formulated for aging skin. It’s ideal for anyone seeking anti-aging skincare or a skin renewing treatment to address fine lines, wrinkles, dullness, and uneven texture. Recommended for mature or prematurely-aging skin, those experiencing fine lines, wrinkles, and loss of firmness. This leave-on exfoliant supports natural surface renewal for smoother, brighter, and more youthful-looking skin.
Phyto Nature E² features a next-generation Regenerative Exosome Blend with plant-based exosomes that act in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles. Pumpkin Enzyme exfoliates to reveal brighter, smoother skin daily. The Botanical Blend with Phyto Glycogen + Prickly Pear brightens and smooths skin, while Bio-Fermented Acetyl Glucosamine hydrates and provides antioxidant protection.
This anti-aging leave-on accelerates skin regeneration, visibly reduces fine lines and wrinkles, and resurfaces skin to improve brightness, texture, and smoothness. Daily exfoliating enzymes clear away dull surface cells, and regenerative exosomes act in multiple layers to diminish fine lines and wrinkles in as little as two weeks**.
Improves natural skin regeneration by up to 86% versus untreated skin*.
Exosomes are microscopic vesicles that act as cell messengers, enhancing communication between skin cells. In skincare, exosomes help support natural skin regeneration and renewal. Phyto Nature E² uses plant-based exosomes to reinforce cellular renewal and surface resurfacing, making it one of the most advanced exosome skin care products for at-home face treatments.
Exosomes in Phyto Nature E² promote natural skin regeneration and cellular communication, helping improve fine lines, dullness, and uneven texture. Enzymes enhance the benefits with daily exfoliation and help maintain smoother, brighter, and more youthful-looking skin.
Phyto Nature E² has a silky, lightweight texture that absorbs quickly without leaving a greasy residue. Its smooth, nourishing, layerable texture makes it easy to use with other leave-ons or moisturizers while providing gentle, daily skin resurfacing.
Apply Phyto Nature E² to clean skin as the first step after cleansing. Allow it to absorb fully before applying moisturizer or serum. Use twice daily, morning and night, to maximize the benefits of this antiaging, skin-renewing leave-on.
Yes. Phyto Nature E² layers easily with other leave-ons, moisturizers, or treatments. Its lightweight, silky texture supports both exfoliation and skin regeneration while integrating seamlessly into any daily skincare routine.
Phyto Nature E² is formulated for daily exfoliation and anti-aging benefits. Those with sensitive skin should patch test first. The plant-based exosomes and gentle Pumpkin Enzyme work together to support skin renewing and resurfacing without irritation for most users.
Visible improvements in skin smoothness, brightness, and fine lines may appear within two weeks of twice-daily use. Continued use supports long-term skin regeneration, leaving skin softer, firmer, and more radiant over time.
or 4 payments of $39.50 with or
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phyto nature e² regenerating daily exosome leave-on treatment
Overall rating: 4.8030305 / 5 from 594 reviews.
Phyto Nature e² is a lightweight, silky leave-on product that visibly smooths and supports skin regeneration. It is formulated with next-gen exosomes and enzymes to improve natural regeneration by 86%. Customers rave about its ability to make skin look fresher, brighter, and more awake, while also feeling silky and absorbing quickly without residue.
Review topics: ["size","absorbs","results","issues","ingredients","irritation","improvement","works","wrinkles","weight","smell","use","quality","fragrance","feels","lines","texture","packaging","value","difference","formula","skin","looks","effect","glow","face","complexion","serum","bottle","residue"].
"I want to love this product but after using it consistently twice per day I just don't see a difference. I like the way the product feels. It absorbs nicely and smells great but for the price I would like to see at least a tiny difference. I am going to finish this bottle and perhaps my results will improve."
"I have been really enjoying this product line. Not only have I personally seen a difference in my complexion, but a close friend of mine commented last week saying, “your skin looks amazing!” Such a huge compliment because I have always struggled with acne, scarring, and uneven complexion. I will continue to use this line including serum and moisturizer thanks to the verifiable results!"
"I’ve been using this product twice a day, for 3 1/2 weeks and it’s absolutely lessened the appearance of the wrinkles on my forehead which is my “problem” area. I took pictures the first night I tried it out and then again last night to compare and feel that there’s a noticeable improvement. My only complaint is that it doesn’t work well with my foundation, it causes pilling. Regardless of that, I’m very pleased with this product and will continue to purchase."
"This is the best treatment skin care I've been using for 14 days and see big changes with my skin and see big changes . I used this after shower first skin care then Incorporate it with other dermatologica skin care . It's pricey but worth the investment as I know it will change my skin in the long haul . best skin care investment I think it's worth it as I'm looking forward for big changes in my skin care best anti-aging skin care treatment."
"I've been using Phyto Nature E² for a few weeks and really enjoy the texture and how my skin feels after. It absorbs quickly, layers well under moisturizer, and my skin looks smoother and more refreshed overall."
"Woww. Es un seremos increíble y combina perfecto con el resto de la linea. El tamaño es ideal por su precio. Refrescante. Com muy muy buenos resultados tan solo a pocas semanas de iniciar el uso. Recomiendo mucho no solo este serum, si no, toda la linea. Amo con locura estos productos con resultados reales."
"I have been using this for a few weeks now and so far so good. I can tell my forehead lines are slightly reduced and the marionette lines around my mouth are also slightly improved. I think with a few months of use I should see more changes. It has not been irritating to my skin and I like the light scent."
"Initially I was skeptical about changing the line I use "aging smart" then I decide why not? I ordered this product from Ulta a month ago and I am super happy with the results, the only downside is if I do not use it one night I can see the difference the next morning. So you must be consitent to maintain the yourger looking skin you are desiring to see. Overall great product, great results. Worth every penny."
"I've been using Phyto Nature E² Regenerating Daily and I'm really impressed with the results. My skin looks smoother, healthier, and noticeably more youthful. It feels hydrated without being greasy, and my complexion has a nice glow. After using it consistently, I've noticed my skin looks firmer and more refreshed. It's become one of my favorite skincare products, and I would definitely recommend it to anyone looking to improve the overall appearance of their skin."
"This is the best product to date. It is the first thing i put on after I cleanse my face. It blends in to the perfect combination of hydration and glow. After applying this i apply the serum of choice. This product is a game changer."
renew + resurface
hydrates and combats skin aging
exfoliates, smooths, brightens
tightens, tones, sculpts
reduces fine lines and hydrates
treats and prevents body breakouts
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