recommended for:
Daily exosome leave-on visibly smooths and supports skin regeneration. Formulated with next-gen exosomes and enzymes, this lightweight, silky leave-on helps reawaken skin’s natural surface renewal process, improving natural regeneration by 86%.*
Exfoliating enzymes help clear away dull surface cells, revealing smoother, brighter skin. A regenerative exosome blend acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles. In an independent clinical study, fine lines and wrinkles were visibly diminished in 2 weeks.*
*Versus untreated skin. Based on in vitro testing.
**Results at 2 weeks, based on a reduction in visible signs of skin aging in an independent clinical study with 32 subjects, 2 applications/day.
Apply to clean skin. Allow to absorb, then follow with the rest of your skin care routine. Use twice daily.
Key Ingredients:
Pumpkin enzyme: Exfoliates to reveal brighter, smoother skin daily
Regenerative exosome blend: Acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles
Botanical blend with phyto glycogen + prickly pear: Visibly brightens and smooths
Bio-fermented acetyl glucosamine: Hydrates and provides antioxidant protection
Water/Aqua/Eau, Lactobacillus/Pumpkin Ferment Extract, Propanediol, Lactococcus Ferment Lysate, Ethoxydiglycol, Hydrolyzed Soy Protein, Acetyl Glucosamine, Hydroxyacetophenone, Lactic Acid, Hydrolyzed Opuntia Ficus-Indica Flower Extract, Helianthus Annuus (Sunflower) Seed Oil, Citrus Aurantium Bergamia (Bergamot) Fruit Oil, Citrus Limon (Lemon) Peel Oil, Citrus Aurantium Dulcis (Orange) Peel Oil, Salvia Sclarea (Clary) Oil, Pyrus Malus (Apple) Fruit Extract, Viola Odorata Leaf Extract, Acacia Senegal Gum Extract, Curcuma Longa (Turmeric) Root Extract, Mucor Miehei Extract, Lavandula Spica (Lavender) Flower/Leaf/Stem Extract, Rosmarinus Officinalis (Rosemary) Leaf Oil, Litsea Cubeba Fruit Oil, Camellia Japonica Flower Extract, Glycerin, Mentha Piperita (Peppermint) Oil, Butylene Glycol, Lactobacillus Ferment, Glycogen, Urea, Caprylyl Glycol, Phospholipids, Glucosamine HCl, Xanthan Gum, PEG-40 Hydrogenated Castor Oil, 1,2-Hexanediol, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Citric Acid, Polyacrylate Crosspolymer-6, Acacia Senegal Gum, Sodium Chloride, Sodium Citrate, Disodium EDTA, Sodium Benzoate, Potassium Sorbate, Limonene, Linalool, Citral.
Dermalogica is dedicated to maintaining the accuracy of the ingredient lists on this website. However, because ingredients are subject to change, we cannot guarantee that these lists are complete, up-to-date and/or error-free. For an accurate listing of ingredients in each product, please refer to your product packaging.
Materials: Bottle: Glass, Pump/cap: Mixed material, Carton: Paper
What’s Recyclable: The bottle of this Dermalogica product is fully recyclable. The paper used in this carton is recyclable and comes from FSC certified responsibly managed forests.
How to Recycle: Ensure bottle is as empty as possible and place in recycling bin. Dispose of pump and cap in waste bin. Place carton in its recycling bin.
Recycling is subject to local policies and facilities.
Phyto Nature E² is a regenerating daily leave-on formulated for aging skin. It’s ideal for anyone seeking anti-aging skincare or a skin renewing treatment to address fine lines, wrinkles, dullness, and uneven texture. Recommended for mature or prematurely-aging skin, those experiencing fine lines, wrinkles, and loss of firmness. This leave-on exfoliant supports natural surface renewal for smoother, brighter, and more youthful-looking skin.
Phyto Nature E² features a next-generation Regenerative Exosome Blend with plant-based exosomes that act in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles. Pumpkin Enzyme exfoliates to reveal brighter, smoother skin daily. The Botanical Blend with Phyto Glycogen + Prickly Pear brightens and smooths skin, while Bio-Fermented Acetyl Glucosamine hydrates and provides antioxidant protection.
This anti-aging leave-on accelerates skin regeneration, visibly reduces fine lines and wrinkles, and resurfaces skin to improve brightness, texture, and smoothness. Daily exfoliating enzymes clear away dull surface cells, and regenerative exosomes act in multiple layers to diminish fine lines and wrinkles in as little as two weeks**.
Improves natural skin regeneration by up to 86% versus untreated skin*.
Exosomes are microscopic vesicles that act as cell messengers, enhancing communication between skin cells. In skincare, exosomes help support natural skin regeneration and renewal. Phyto Nature E² uses plant-based exosomes to reinforce cellular renewal and surface resurfacing, making it one of the most advanced exosome skin care products for at-home face treatments.
Exosomes in Phyto Nature E² promote natural skin regeneration and cellular communication, helping improve fine lines, dullness, and uneven texture. Enzymes enhance the benefits with daily exfoliation and help maintain smoother, brighter, and more youthful-looking skin.
Phyto Nature E² has a silky, lightweight texture that absorbs quickly without leaving a greasy residue. Its smooth, nourishing, layerable texture makes it easy to use with other leave-ons or moisturizers while providing gentle, daily skin resurfacing.
Apply Phyto Nature E² to clean skin as the first step after cleansing. Allow it to absorb fully before applying moisturizer or serum. Use twice daily, morning and night, to maximize the benefits of this antiaging, skin-renewing leave-on.
Yes. Phyto Nature E² layers easily with other leave-ons, moisturizers, or treatments. Its lightweight, silky texture supports both exfoliation and skin regeneration while integrating seamlessly into any daily skincare routine.
Phyto Nature E² is formulated for daily exfoliation and anti-aging benefits. Those with sensitive skin should patch test first. The plant-based exosomes and gentle Pumpkin Enzyme work together to support skin renewing and resurfacing without irritation for most users.
Visible improvements in skin smoothness, brightness, and fine lines may appear within two weeks of twice-daily use. Continued use supports long-term skin regeneration, leaving skin softer, firmer, and more radiant over time.
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Overall rating: 4.808743 / 5 from 549 reviews.
Phyto Nature e² is a lightweight, silky leave-on product that visibly smooths and supports skin regeneration. It is formulated with next-gen exosomes and enzymes to improve natural regeneration by 86%. Customers rave about its ability to make skin look fresher, brighter, and more awake, while also feeling silky and absorbing quickly without residue.
Review topics: ["size","absorbs","results","issues","ingredients","irritation","improvement","works","wrinkles","weight","smell","use","quality","fragrance","feels","lines","texture","packaging","value","difference","formula","skin","looks","effect","glow","face","complexion","serum","bottle","residue"].
"I’ve only been using the products for two weeks so I can’t really say that it’s a good thing. I’ve had to cut back to once a day as I have experienced stinging. That being said I have loved all Dermalogica for a long time and I have high hopes. At 74 years old my skin looks great and I give most of the credit to Dermalogica,"
"I have noticed a difference in my skin since I've started using this - it really has made my skin become smoother and brighter and reduced some of my facial lines as well. I am purchasing my 2nd bottle and look forward to more improvement over time."
"I am seriously shocked at all the 5 star reviews for this product. I thought for the price it was going to give my skin some improvement but it truly did NOTHING. I am 31 and have some shallow forehead wrinkles that formed in the last year that I thought this would flatten nicely for how costly it is. It truly did nothing. I used morning and night as directed for 3 weeks and I have ZERO wrinkle improvement. It made my acne prone skin break out. The only reason it gets two stars is because my skin is sensitive and my skin did tolerate it well (did not burn or flake) besides for it causing acne. I'm really disappointed as I was counting on this to work! I am returning it."
"Dermalogica’s Skin Sculptor is a lightweight body serum that sinks effortlessly into the skin without leaving a greasy residue. It effectively hydrates and moisturizes my skin, resulting in a soft and smooth texture. While I haven’t used it for an extended period to assess its toning and firming effects, I’m eager to observe its performance with prolonged use. You have to see my neck pictures. . and I have sensitive skin and still was able to use product all over my body."
"This has been a great pre-treatment before the Futurecode Booster. I have seen softer and a brighter complexion. When I paid this before the Futurecode Booster, both my skin look more youthful and flawless. I already have a backup !"
"I fell in love with this on the first application. I seriously look forward to using it 2x a day!! I use the eye lift cream too and have loved it since its debut. I'm eager to try the rest of the whole phyto line. Really good stuff I don't want to ever run out!"
"I just received this product and was excited to use it for the first time. It definitely feels good on my skin and improves texture immediately. My skin is really sensitive so i am happy to report it is very gentle and no irritation."
"I can see the changes happening. Smoother, younger looking complexion."
"I have been using this twice a day as directed, for about 2 weeks now. I LOVE IT!!! I can already see a difference in my wrinkles, way softer, my face has more plumpness to it, and my skin is so soft. You have won me over!"
"I love this product. I was not interested in skincare routines until I used this product. It literally changed my life! After a week I had seen results and felt inspired to add more Dermologica products to my routine. I love my new routine!"
renew + resurface
hydrates and combats skin aging
exfoliates, smooths, brightens
tightens, tones, sculpts
reduces fine lines and hydrates
treats and prevents body breakouts
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