recommended for:
Daily exosome leave-on visibly smooths and supports skin regeneration. Formulated with next-gen exosomes and enzymes, this lightweight, silky leave-on helps reawaken skin’s natural surface renewal process, improving natural regeneration by 86%.*
Exfoliating enzymes help clear away dull surface cells, revealing smoother, brighter skin. A regenerative exosome blend acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles. In an independent clinical study, fine lines and wrinkles were visibly diminished in 2 weeks.*
*Versus untreated skin. Based on in vitro testing.
**Results at 2 weeks, based on a reduction in visible signs of skin aging in an independent clinical study with 32 subjects, 2 applications/day.
In an 8-week independent clinical study, 32 subjects applied Phyto Nature E² twice daily. In laboratory (in vitro) testing, the formula improved skin's natural regeneration by up to 86% versus untreated skin. Fine lines and wrinkles were visibly diminished in as little as 2 weeks of twice-daily use, and after just one use consumers perceived that their skin looked and acted younger. With continued daily use, skin looks smoother, brighter and more refined.
86%
improved skin's natural regeneration vs untreated skin*
2 weeks
fine lines and wrinkles visibly diminished**
*Versus untreated skin, based on in vitro testing.
**Independent clinical study, 32 subjects, 2 applications/day.
Apply to clean skin. Allow to absorb, then follow with the rest of your skin care routine. Use twice daily.
![["Fresh pumpkin representing the pumpkin enzyme used for gentle enzymatic exfoliation."]](https://cdn.shopify.com/s/files/1/0420/7683/1896/files/01_-_pumpkin_enzyme.jpg?v=1790113260)
Exfoliates to reveal brighter, smoother skin daily.
![["Clear gel texture representing the plant-derived regenerative exosome blend."]](https://cdn.shopify.com/s/files/1/0420/7683/1896/files/02_-_regenerative_exosome_blend.jpg?v=1790113260)
Acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles.1
![["Smooth white cream texture representing the botanical blend with phyto glycogen + prickly pear."]](https://cdn.shopify.com/s/files/1/0420/7683/1896/files/88_phyto-glycogen-prickly-pear_60822429-71d9-4702-be24-2112b2e12dd0.jpg?v=1784309294)
Visibly brightens and smooths.
![["Soft white sculpted texture representing bio-fermented acetyl glucosamine."]](https://cdn.shopify.com/s/files/1/0420/7683/1896/files/11_glucosamine-hcl_6750fa2d-f10b-4ca4-928e-78d7ee49532e.jpg?v=1784309275)
Hydrates and provides antioxidant protection.2
Water/Aqua/Eau, Lactobacillus/Pumpkin Ferment Extract, Propanediol, Lactococcus Ferment Lysate, Ethoxydiglycol, Hydrolyzed Soy Protein, Acetyl Glucosamine, Hydroxyacetophenone, Lactic Acid, Hydrolyzed Opuntia Ficus-Indica Flower Extract, Helianthus Annuus (Sunflower) Seed Oil, Citrus Aurantium Bergamia (Bergamot) Fruit Oil, Citrus Limon (Lemon) Peel Oil, Citrus Aurantium Dulcis (Orange) Peel Oil, Salvia Sclarea (Clary) Oil, Pyrus Malus (Apple) Fruit Extract, Viola Odorata Leaf Extract, Acacia Senegal Gum Extract, Curcuma Longa (Turmeric) Root Extract, Mucor Miehei Extract, Lavandula Spica (Lavender) Flower/Leaf/Stem Extract, Rosmarinus Officinalis (Rosemary) Leaf Oil, Litsea Cubeba Fruit Oil, Camellia Japonica Flower Extract, Glycerin, Mentha Piperita (Peppermint) Oil, Butylene Glycol, Lactobacillus Ferment, Glycogen, Urea, Caprylyl Glycol, Phospholipids, Glucosamine HCl, Xanthan Gum, PEG-40 Hydrogenated Castor Oil, 1,2-Hexanediol, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Citric Acid, Polyacrylate Crosspolymer-6, Acacia Senegal Gum, Sodium Chloride, Sodium Citrate, Disodium EDTA, Sodium Benzoate, Potassium Sorbate, Limonene, Linalool, Citral.
Dermalogica is dedicated to maintaining the accuracy of the ingredient lists on this website. However, because ingredients are subject to change, we cannot guarantee that these lists are complete, up-to-date and/or error-free. For an accurate listing of ingredients in each product, please refer to your product packaging.
Materials: Bottle: Glass, Pump/cap: Mixed material, Carton: Paper
What’s Recyclable: The bottle of this Dermalogica product is fully recyclable. The paper used in this carton is recyclable and comes from FSC certified responsibly managed forests.
How to Recycle: Ensure bottle is as empty as possible and place in recycling bin. Dispose of pump and cap in waste bin. Place carton in its recycling bin.
Recycling is subject to local policies and facilities.
awarded and mentioned in 2026
External scientific references supporting the ingredient science referenced on this page (not our clinical testing).
Mature or prematurely-aging skin, and anyone looking to address fine lines and wrinkles, loss of firmness and elasticity, dullness, and uneven texture. Gentle enough for daily use.
A next-generation Regenerative Exosome Blend (plant-based exosomes with Turmeric stem cells and Acacia Senegal); Pumpkin Enzyme; a Botanical Blend of Phyto Glycogen and Prickly Pear; and bio-fermented Acetyl Glucosamine.
Exosomes are microscopic messengers between skin cells that support natural regeneration and renewal; E² uses plant-based exosomes to reinforce cellular communication and surface resurfacing.
E² delivers plant-based exosomes in a daily at-home format. It complements in-clinic treatments (such as Dermalogica PRO's Exo Booster) rather than replacing them. Using it daily helps maintain and extend results between visits.
Yes, plant-derived (Turmeric stem cells and Acacia Senegal), and all current Dermalogica formulas are PETA-certified vegan.
No. E² is developed and tested to stay stable at room temperature. Just keep it out of direct sunlight and excessive heat.
No added synthetic fragrance. Any scent is naturally occurring from the botanical and citrus oils in the formula (which naturally contain limonene, linalool and citral). Patch test first if sensitive.
Apply to clean skin as the first step after cleansing. Allow it to absorb, then follow with the rest of your routine. Use twice daily; in the morning, always finish with SPF.
Yes: apply E² first, then the Phyto Nature Firming Serum; it can also be used with Dynamic Skin Retinol Serum in your PM routine.
E² uses gentle enzymatic exfoliation (Pumpkin Enzyme loosens the bonds between dead surface cells rather than scrubbing). If your skin is sensitive, patch test first and introduce it slowly, adjusting frequency if needed. Avoid the eye area and broken skin.
Visible improvements in smoothness, brightness and fine lines can appear within 2 weeks of twice-daily use (32-subject study). In vitro, E² improved skin's natural regeneration by up to 86% versus untreated skin.
Silky and lightweight. It absorbs quickly without a greasy residue and layers easily under serums or moisturizers.
Sarah
Licensed Professional Skin Therapist
What sets E2 apart is that its exfoliation is supported by exosomes, which help enhance communication between skin cells and support overall skin health. This means you get the benefits of smoother texture, improved clarity, and more radiant skin without compromising the barrier.
via the CIRCLE community (comment) posted in 2026 source
or 4 payments of $39.50 with or
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phyto nature e² regenerating daily exosome leave-on treatment
Overall rating: 4.795069 / 5 from 649 reviews.
The Phyto Nature E² Regenerating Daily Exosome Leave-On Treatment is praised for its noticeable difference, pleasant herbal scent, silky and lightweight feel, and impressive results. It visibly diminishes fine lines and wrinkles, leaving skin smoother, softer, and more balanced. The product absorbs easily without leaving any residue.
Review topics: ["size","smell","weight","issues","results","quality","feels","shipping","improvement","skin","packaging","lines","texture","looks","absorbs","serum","glow","wrinkles","formula","difference","face","irritation","bottle","change","complexion","ingredients","boost","nature","residue","reduction"].
"When I added phyto nature e² to my routine, I noticed a feeling of renewal and a fresh boost to ny skin's properties. Everyday, I use it, and I love how my skin is doing right now. I feel like I have a whole new look! I love the photo nature e², I will continue to keep it as part of my daily routine."
"Since using this product, my skin has improved in overal appearance. Normally I wouldn't credit one product as I do really believe its about being consistent with your regimen and nutrition but this is the one product I've been seriously consistent with so I must give it credit. Its not a drastic overnight change, but I do feel like I've had less issues (wrinkles, tone, texture) since using this product. Plus it smells amazing so its staying!"
"My husband and I both like using this product. Our skin feels smooth and softer after each use. Feels like a high end product but we definitely don’t see the results of the “2 week result photos” that are shown for advertisement! I wish my forehead wrinkles disappeared like that! Lol"
"Non-sticky lightweight serum that lives up to the hype. Doesn't break me out, making it easy to commit to using consistently. I've been using this and the smart density eye serum everyday for the last several weeks and it's been a power combo. Hefty bottle is a nice touch considering the price."
"I am so impressed. I have spent money on many many serums. This one hit all the right notes. I am delaying my botox treatment because its keeping my forehead wrinkles at bay and I have been getting botox for 3yrs now. This is the best smelling mild serum and so moisturizing, I don't even use a moisturizer after so all credit goes to this serum. Please don't change this serum!"
"Miracle product! I absolutely love this and I have shared with my mom and aunt and they absolutely love it too! Dermalogica is the crème de la crème in beauty and as a licensed aesthetician I am such a believer in their products! I have very sensitive skin and everything I’ve tried from dermalogica I am never disappointed in but this product is amazing! It really does what it says - love that it smooths my forehead, is super hydrating and the enzymes are just amazing! Give it a try!"
"I used my first bottle for about four months and am now on my second bottle. So far, I honestly haven’t noticed any significant improvement in my skin texture or fine lines. If anything, I’ve noticed only a very slight reduction in oiliness. Despite the lack of noticeable results so far, I decided to purchase a second bottle and continue using the product to give it a fair chance. I’m hoping that with longer, consistent use, I may eventually see more visible improvement."
"Regenerating truly lessens appearance of fine wrinkles and the gleaning gel is gentle and leaves skin feeling clean and refreshed!"
"I am a huge fan of phyto nature e regenerating. when I added this to my routine it was like night and day. I apply this right after I shower before any other product. it has made all the difference in my routine. Please just try this once and you will love the results."
"I really like this product. It's not Botox and won't get rid of lines but I noticed a difference in some newer ones looking less noticable and just the overall appearance of my skin improved. I will continue to use and buy and find it worth the money. It's a big bottle and lasts a long time."
expert-level solutions
3-step cleansing essentials
smoother skin face + body duo
firm + lift trio
daily essentials
iconic exfoliant bundle
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