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phyto nature e²

renew + resurface

phyto nature e²

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Regular price

$158

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recommended for:

  • mature or prematurely-aging skin
  • fine lines and wrinkles
  • loss of firmness and elasticity
  • GLP-1 users

Daily exosome leave-on visibly smooths and supports skin regeneration. Formulated with next-gen exosomes and enzymes, this lightweight, silky leave-on helps reawaken skin’s natural surface renewal process, improving natural regeneration by 86%.*

Exfoliating enzymes help clear away dull surface cells, revealing smoother, brighter skin. Regenerative exosomes, known for their role as cell messengers, act in multiple layers of skin’s surface to visibly diminish fine lines and wrinkles in as little as two weeks.**

 

*Versus untreated skin. Based on in vitro testing.

**Results at 2 weeks, based on a reduction in visible signs of skin aging in an independent clinical study with 32 subjects, 2 applications/day.

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benefits

  • Regenerative exosome blend helps diminish the appearance of fine lines + wrinkles
  • Accelerates skin's natural cellular renewal
  • Resurfaces to reveal brighter, smoother skin every day
how to use

Apply to clean skin. Allow to absorb, then follow with the rest of your skin care routine. Use twice daily. 

ingredients

Key Ingredients:

  • Pumpkin enzyme: Exfoliates to reveal brighter, smoother skin daily

  • Regenerative exosome blend: Acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles

  • Botanical blend with phyto glycogen + prickly pear: Visibly brightens and smooths

  • Bio-fermented acetyl glucosamine: Hydrates and provides antioxidant protection


Water/Aqua/Eau, Lactobacillus/Pumpkin Ferment Extract, Propanediol, Lactococcus Ferment Lysate, Ethoxydiglycol, Hydrolyzed Soy Protein, Acetyl Glucosamine, Hydroxyacetophenone, Lactic Acid, Hydrolyzed Opuntia Ficus-Indica Flower Extract, Helianthus Annuus (Sunflower) Seed Oil, Citrus Aurantium Bergamia (Bergamot) Fruit Oil, Citrus Limon (Lemon) Peel Oil, Citrus Aurantium Dulcis (Orange) Peel Oil, Salvia Sclarea (Clary) Oil, Pyrus Malus (Apple) Fruit Extract, Viola Odorata Leaf Extract, Acacia Senegal Gum Extract, Curcuma Longa (Turmeric) Root Extract, Mucor Miehei Extract, Lavandula Spica (Lavender) Flower/Leaf/Stem Extract, Rosmarinus Officinalis (Rosemary) Leaf Oil, Litsea Cubeba Fruit Oil, Camellia Japonica Flower Extract, Glycerin, Mentha Piperita (Peppermint) Oil, Butylene Glycol, Lactobacillus Ferment, Glycogen, Urea, Caprylyl Glycol, Phospholipids, Glucosamine HCl, Xanthan Gum, PEG-40 Hydrogenated Castor Oil, 1,2-Hexanediol, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Citric Acid, Polyacrylate Crosspolymer-6, Acacia Senegal Gum, Sodium Chloride, Sodium Citrate, Disodium EDTA, Sodium Benzoate, Potassium Sorbate, Limonene, Linalool, Citral.


Dermalogica is dedicated to maintaining the accuracy of the ingredient lists on this website. However, because ingredients are subject to change, we cannot guarantee that these lists are complete, up-to-date and/or error-free. For an accurate listing of ingredients in each product, please refer to your product packaging.

sustainability

Materials: Bottle: Glass, Pump/cap: Mixed material, Carton: Paper

What’s Recyclable: The bottle of this Dermalogica product is fully recyclable. The paper used in this carton is recyclable and comes from FSC certified responsibly managed forests.

How to Recycle: Ensure bottle is as empty as possible and place in recycling bin. Dispose of pump and cap in waste bin. Place carton in its recycling bin.


Recycling is subject to local policies and facilities.

                                                                                                                                                                                                                                                                                                 

Learn more about Dermalogica's sustainability efforts here.

FAQs
Who is this leave-on recommended for?

Phyto Nature E² is a regenerating daily leave-on formulated for aging skin. It’s ideal for anyone seeking anti-aging skincare or a skin renewing treatment to address fine lines, wrinkles, dullness, and uneven texture. Recommended for mature or prematurely-aging skin, those experiencing fine lines, wrinkles, and loss of firmness. This leave-on exfoliant supports natural surface renewal for smoother, brighter, and more youthful-looking skin.

What are the key active ingredients?

Phyto Nature E² features a next-generation Regenerative Exosome Blend with plant-based exosomes that act in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles. Pumpkin Enzyme exfoliates to reveal brighter, smoother skin daily. The Botanical Blend with Phyto Glycogen + Prickly Pear brightens and smooths skin, while Bio-Fermented Acetyl Glucosamine hydrates and provides antioxidant protection.

What benefits does it provide?

This anti-aging leave-on accelerates skin regeneration, visibly reduces fine lines and wrinkles, and resurfaces skin to improve brightness, texture, and smoothness. Daily exfoliating enzymes clear away dull surface cells, and regenerative exosomes act in multiple layers to diminish fine lines and wrinkles in as little as two weeks**. 

Improves natural skin regeneration by up to 86% versus untreated skin*.

What are exosomes in skincare?

Exosomes are microscopic vesicles that act as cell messengers, enhancing communication between skin cells. In skincare, exosomes help support natural skin regeneration and renewal. Phyto Nature E² uses plant-based exosomes to reinforce cellular renewal and surface resurfacing, making it one of the most advanced exosome skin care products for at-home face treatments.

What do exosomes do for skin?

Exosomes in Phyto Nature E² promote natural skin regeneration and cellular communication, helping improve fine lines, dullness, and uneven texture. Enzymes enhance the benefits with daily exfoliation and help maintain smoother, brighter, and more youthful-looking skin.

What is the texture like?

Phyto Nature E² has a silky, lightweight texture that absorbs quickly without leaving a greasy residue. Its smooth, nourishing, layerable texture makes it easy to use with other leave-ons or moisturizers while providing gentle, daily skin resurfacing.

How do I use this leave-on?

Apply Phyto Nature E² to clean skin as the first step after cleansing. Allow it to absorb fully before applying moisturizer or serum. Use twice daily, morning and night, to maximize the benefits of this antiaging, skin-renewing leave-on.

Can I layer it with other products?

Yes. Phyto Nature E² layers easily with other leave-ons, moisturizers, or treatments. Its lightweight, silky texture supports both exfoliation and skin regeneration while integrating seamlessly into any daily skincare routine.

Is it suitable for sensitive skin?

Phyto Nature E² is formulated for daily exfoliation and anti-aging benefits. Those with sensitive skin should patch test first. The plant-based exosomes and gentle Pumpkin Enzyme work together to support skin renewing and resurfacing without irritation for most users.

When can I expect to notice differences?

Visible improvements in skin smoothness, brightness, and fine lines may appear within two weeks of twice-daily use. Continued use supports long-term skin regeneration, leaving skin softer, firmer, and more radiant over time.

Real Skin, Real Results

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