Moisturizer my skin. I feel
"Moisturizer my skin. I feel my skin smooth and soft"
Hydrating Collagen Trio Offer | You're $100.00 away from 3 free gifts + free shipping
free shipping on orders $20+. no code needed. see details
analyze your skin with face mapping. learn more
recommended for:
Skin care just got smarter. Next-gen smart serum delivers what your skin needs, when and where it needs it. Delivers a personalized response every time, for healthier-looking skin over time.
SmartResponse technology helps stop skin damage before it starts – using four smart actives which, when triggered, hydrate, brighten, soothe, and address the appearance of fine lines and wrinkles in response to skin’s changing needs. Oligosaccharides from hydrolyzed Beta Glucan respond to dehydration signals, helping skin to maintain optimal hydration levels. Hydrolyzed Wheat Flour, rich in arabinoxylo-oligosaccharides, activates as needed to brighten and help reduce the appearance of dark spots. Antioxidant-rich Japanese Cornelia Cherry helps to protect stressed skin against free radicals, helping to soothe and reduce the appearance of redness. Plant-based Mannose-6-Phosphate visibly smooths and provides a firming effect, responding to the first signs of visible skin aging to help improve the look of fine lines and wrinkles. Lactic Acid, an Alpha Hydroxy Acid (AHA), helps to brighten and smooth skin.
Apply each morning and night after cleansing and toning. Allow one minute for product absorption.

japanese cornelia cherry
helps soothe and reduce the appearance of redness

mannose-6-phosphate
visibly smooths and provides a firming effect

hydrolyzed wheat flour
brightens and helps reduce the appearance of dark spots
Water/Aqua/Eau, Glycerin, Coco-Caprylate/Caprate, PPG24-Glycereth-24, Niacinamide, Butylene Glycol, 1,2-Hexanediol, Sodium Acrylates Crosspolymer-2, C18-36 Acid Triglyceride, Sodium Polyacryloyldimethyl Taurate, Hydroxyacetophenone, Jojoba Esters, Olive Oil Decyl Esters, Phytosterols, Cornus Officinalis Fruit Extract, Hydrolyzed Wheat Flour, Sodium Mannose Phosphate, Phytosteryl Macadamiate, Hydrolyzed BetaGlucan, Mimosa Tenuiflora Bark Extract, Ilex Paraguariensis Leaf Extract, Sea Salt, Ferula Galbaniflua (Galbanum) Resin Oil, Helianthus Annuus (Sunflower) Seed Oil, Citrus Aurantium Bergamia (Bergamot) Fruit Extract, Citrus Aurantium Dulcis (Orange) Peel Oil, Juniperus Virginiana Oil, Pelargonium Graveolens Flower Oil, Vetiveria Zizanoides Root Oil, Prunus Amygdalus Amara (Bitter Almond) Kernel Oil, Chlorella Vulgaris Extract, Dipteryx Odorata Seed Extract, Lactic Acid, Bentonite, C12-18 Acid Triglyceride, Squalene, Tocopherol, Sodium Acetylated Hyaluronate, Mannose, Citric Acid, Hydrated Silica, Sodium Benzoate, Potassium Sorbate, Citronellol, Geraniol, Coumarin, Linalool, Limonene.
Dermalogica is dedicated to maintaining the accuracy of the ingredient lists on this website. However, because ingredients are subject to change, we cannot guarantee that these lists are complete, up-to-date and/or error-free. For an accurate listing of ingredients in each product, please refer to your product packaging.
1.0 oz:
Materials: Bottle/Pump: Mixed Material, Cap: PP, Carton: Paper
What’s Recyclable: The paper used in this carton is recyclable and comes from FSC certified responsibly managed forests.
How to Recycle: Place carton in its recycling bin.
Recycling is subject to local policies and facilities.
To learn more about Dermalogica's sustainability efforts, please click here.
Recommended for all skin types, including dryness/dehydration, fine lines and wrinkles, enlarged pores, sensitivity, and redness.
Delivers targeted hydration, brightening, soothing, and helps address the appearance of fine lines and uneven tone using SmartResponse actives.
The key ingredients include Oligosaccharides from hydrolyzed Beta Glucan respond to dehydration signals, helping skin to maintain optimal hydration levels. Hydrolyzed Wheat Flour, rich in arabinoxylo-oligosaccharides, activates as needed to brighten and help reduce the appearance of dark spots. Antioxidant-rich Japanese Cornelia Cherry helps to protect stressed skin against free radicals, helping to soothe and reduce the appearance of redness. Plant-based Mannose-6-Phosphate visibly smooths and provides a firming effect, responding to the first signs of visible skin aging to help improve the look of fine lines and wrinkles.
Apply to cleansed skin. Use in the morning and/or evening, follow with your moisturizer, and allow it to absorb before applying makeup.
Lightweight gel-cream texture that absorbs and layers well; many users report a dewy, hydrated finish.
Dermalogica formulas never use artificial fragrances. However, botanical extracts and essential oils included for skin benefits may have a natural scent. Some users may notice a subtle fragrance.
Yes - it layers well under moisturizers and makeup and is commonly used within multi-step routines.
Formulated to soothe and reduce the appearance of redness for many users. If you have known sensitivities, consider a patch test before full use.
or 4 payments of $39.50 with   or  
Couldn't load pickup availability
recommended for:
Skin care just got smarter. Next-gen smart serum delivers what your skin needs, when and where it needs it. Delivers a personalized response every time, for healthier-looking skin over time.
SmartResponse technology helps stop skin damage before it starts – using four smart actives which, when triggered, hydrate, brighten, soothe, and address the appearance of fine lines and wrinkles in response to skin’s changing needs. Oligosaccharides from hydrolyzed Beta Glucan respond to dehydration signals, helping skin to maintain optimal hydration levels. Hydrolyzed Wheat Flour, rich in arabinoxylo-oligosaccharides, activates as needed to brighten and help reduce the appearance of dark spots. Antioxidant-rich Japanese Cornelia Cherry helps to protect stressed skin against free radicals, helping to soothe and reduce the appearance of redness. Plant-based Mannose-6-Phosphate visibly smooths and provides a firming effect, responding to the first signs of visible skin aging to help improve the look of fine lines and wrinkles. Lactic Acid, an Alpha Hydroxy Acid (AHA), helps to brighten and smooth skin.
Apply each morning and night after cleansing and toning. Allow one minute for product absorption.

japanese cornelia cherry
helps soothe and reduce the appearance of redness

mannose-6-phosphate
visibly smooths and provides a firming effect

hydrolyzed wheat flour
brightens and helps reduce the appearance of dark spots
Water/Aqua/Eau, Glycerin, Coco-Caprylate/Caprate, PPG24-Glycereth-24, Niacinamide, Butylene Glycol, 1,2-Hexanediol, Sodium Acrylates Crosspolymer-2, C18-36 Acid Triglyceride, Sodium Polyacryloyldimethyl Taurate, Hydroxyacetophenone, Jojoba Esters, Olive Oil Decyl Esters, Phytosterols, Cornus Officinalis Fruit Extract, Hydrolyzed Wheat Flour, Sodium Mannose Phosphate, Phytosteryl Macadamiate, Hydrolyzed BetaGlucan, Mimosa Tenuiflora Bark Extract, Ilex Paraguariensis Leaf Extract, Sea Salt, Ferula Galbaniflua (Galbanum) Resin Oil, Helianthus Annuus (Sunflower) Seed Oil, Citrus Aurantium Bergamia (Bergamot) Fruit Extract, Citrus Aurantium Dulcis (Orange) Peel Oil, Juniperus Virginiana Oil, Pelargonium Graveolens Flower Oil, Vetiveria Zizanoides Root Oil, Prunus Amygdalus Amara (Bitter Almond) Kernel Oil, Chlorella Vulgaris Extract, Dipteryx Odorata Seed Extract, Lactic Acid, Bentonite, C12-18 Acid Triglyceride, Squalene, Tocopherol, Sodium Acetylated Hyaluronate, Mannose, Citric Acid, Hydrated Silica, Sodium Benzoate, Potassium Sorbate, Citronellol, Geraniol, Coumarin, Linalool, Limonene.
Dermalogica is dedicated to maintaining the accuracy of the ingredient lists on this website. However, because ingredients are subject to change, we cannot guarantee that these lists are complete, up-to-date and/or error-free. For an accurate listing of ingredients in each product, please refer to your product packaging.
1.0 oz:
Materials: Bottle/Pump: Mixed Material, Cap: PP, Carton: Paper
What’s Recyclable: The paper used in this carton is recyclable and comes from FSC certified responsibly managed forests.
How to Recycle: Place carton in its recycling bin.
Recycling is subject to local policies and facilities.
To learn more about Dermalogica's sustainability efforts, please click here.
Recommended for all skin types, including dryness/dehydration, fine lines and wrinkles, enlarged pores, sensitivity, and redness.
Delivers targeted hydration, brightening, soothing, and helps address the appearance of fine lines and uneven tone using SmartResponse actives.
The key ingredients include Oligosaccharides from hydrolyzed Beta Glucan respond to dehydration signals, helping skin to maintain optimal hydration levels. Hydrolyzed Wheat Flour, rich in arabinoxylo-oligosaccharides, activates as needed to brighten and help reduce the appearance of dark spots. Antioxidant-rich Japanese Cornelia Cherry helps to protect stressed skin against free radicals, helping to soothe and reduce the appearance of redness. Plant-based Mannose-6-Phosphate visibly smooths and provides a firming effect, responding to the first signs of visible skin aging to help improve the look of fine lines and wrinkles.
Apply to cleansed skin. Use in the morning and/or evening, follow with your moisturizer, and allow it to absorb before applying makeup.
Lightweight gel-cream texture that absorbs and layers well; many users report a dewy, hydrated finish.
Dermalogica formulas never use artificial fragrances. However, botanical extracts and essential oils included for skin benefits may have a natural scent. Some users may notice a subtle fragrance.
Yes - it layers well under moisturizers and makeup and is commonly used within multi-step routines.
Formulated to soothe and reduce the appearance of redness for many users. If you have known sensitivities, consider a patch test before full use.
smart response serum

Overall rating: 4.7383885 / 5 from 1055 reviews.
Customers love the Dermalogica Smart Response Serum for its ability to hydrate, brighten, and firm skin. The serum is praised for its quick absorption, noticeable results in skin tone and texture, and effective reduction of fine lines. Many users appreciate its smooth, silky texture and pleasant scent.
Review topics: ["improvement","feels","skin","lines","looks","use","difference","serum","smart response serum","dermalogica","moisturizer","skincare"].
"Moisturizer my skin. I feel my skin smooth and soft"
— Rina T. (5/5)
"This serum makes my skin so soft and smooth, its a game changer!"
— Kathryn H. (5/5)
"Can’t live without smart response serum use it every day"
— Julie B. (5/5)
"So good love this for my skin"
— Jovan M. (5/5)
"Felt immediate relief from drynesss"
— Leslie (4/5)
"Love it"
— Oksana (5/5)
"I’ve used Dermalogica for years, and Smart Response Serum is a standout. It leaves my skin feeling renewed, smooth, and deeply hydrated. I’ve even received compliments while wearing only this serum. It’s become an essential in my routine."
— Cecy C. (5/5)
"Have used for 3 days and I love it! Redness has improved and I have sensitive skin but so far so good!!. It’s pricey but I think will last a long time."
— Marilyn (5/5)
"Love this serum and carrying it around when my skin needs a boost of hydration"
— Liz (5/5)
"The bottle design is nice and packaging. Quick delivery! I feel hydrated all day but I'm not sure if it brightens or I feel more glowy for the price. I do love all dermalogica products though."
— Brieann D. (4/5)

renew + resurface

hydrates and combats skin aging

exfoliates, smooths, brightens

tightens, tones, sculpts

reduces fine lines and hydrates

treats and prevents body breakouts
Explore our best-selling products or search for options that support your skin needs.
Shop best sellers
Receive a Pro-Collagen Banking Water Cream (0.24 oz), Pro-Collagen Banking Serum (0.17 oz), and Skin Smoothing Cream (0.24 oz) on orders $100+. No code needed. Offer valid while supplies last on qualifying U.S. purchases made on dermalogica.com from 12:00am PST July 13, 2026 through 11:59pm PST July 18, 2026. May not be combined with any coupon, discount or special offer; or applied to previous purchases. Gifts are non-transferable, non-refundable, non-negotiable and cannot be exchanged, returned, or redeemed for cash or merchandise credit. We reserve the right to substitute gift offered with an item of equal or greater value. We reserve the right to modify, cancel and limit any promotion or offer. We reserve the right to make changes to these terms and conditions at any time and for any reason.
Receive free shipping on all orders $20+. No code needed. Offer valid on qualifying continental U.S. purchases made on dermalogica.com from 12:00am PST July 13, 2026 through 11:59pm PST July 23, 2026. Orders outside the continental U.S. will receive free expedited shipping. May not be combined with any coupon, discount or special offer; applied to previous purchases; or redeemed for cash or merchandise credit. We reserve the right to modify, cancel and limit any promotion or offer. We reserve the right to make changes to these terms and conditions at any time and for any reason.
A current list of skin care products eligible for purchase with HSA or FSA funds is available on our designated eligibility page. For comprehensive information regarding HSA/FSA qualifications and permitted card usage, please refer to our HSA/FSA information page. Eligibility requirements may change, and we reserve the right to modify the list of qualifying products at any time without prior notice.
receive a 3-piece welcome gift with a $125+ purchase when you sign up to our mailing list.
Offer valid on orders $125+. The code to redeem this offer can be found in your sign-up confirmation email. Code must be entered on the cart page to apply. Limit 1 redemption per customer. May not be combined with any coupon, discount or special offer; or applied to previous purchases. Gifts are non-transferable, non-refundable, non-negotiable and cannot be exchanged, returned, or redeemed for cash or merchandise credit. We reserve the right to substitute gift offered with an item of equal or greater value. We reserve the right to modify, cancel and limit any promotion or offer. We reserve the right to make changes to these terms and conditions at any time and for any reason. By clicking SUBSCRIBE, I accept the privacy terms and give my consent to receive Dermalogica marketing e-mails at the e-mail provided. Consent is not a condition of any purchase. Message and data rates may apply. Message frequency varies.
*Savings percentage is not part of a promotional offer and does not constitute a promotional discount.
Offer valid for on all subscription orders. Must be signed up to our rewards program at time of order. No code needed.
Select one free travel size product on orders $20+. Must select in cart page. No code needed. Offer valid on qualifying U.S. purchases made on dermalogica.com. Gifts are non-transferable, non-refundable, non-negotiable and cannot be exchanged, returned, or redeemed for cash or merchandise credit. We reserve the right to substitute gift offered with an item of equal or greater value.
*Savings percentage is based on cost per ounce compared to the primary retail ounce. Savings percentage is not part of a promotional offer and does not constitute a promotional discount.