recommended for:
Daily exosome leave-on visibly smooths and supports skin regeneration. Formulated with next-gen exosomes and enzymes, this lightweight, silky leave-on helps reawaken skin’s natural surface renewal process, improving natural regeneration by 86%.*
Exfoliating enzymes help clear away dull surface cells, revealing smoother, brighter skin. A regenerative exosome blend acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles. In an independent clinical study, fine lines and wrinkles were visibly diminished in 2 weeks.*
*Versus untreated skin. Based on in vitro testing.
**Results at 2 weeks, based on a reduction in visible signs of skin aging in an independent clinical study with 32 subjects, 2 applications/day.
Apply to clean skin. Allow to absorb, then follow with the rest of your skin care routine. Use twice daily.
Key Ingredients:
Pumpkin enzyme: Exfoliates to reveal brighter, smoother skin daily
Regenerative exosome blend: Acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles
Botanical blend with phyto glycogen + prickly pear: Visibly brightens and smooths
Bio-fermented acetyl glucosamine: Hydrates and provides antioxidant protection
Water/Aqua/Eau, Lactobacillus/Pumpkin Ferment Extract, Propanediol, Lactococcus Ferment Lysate, Ethoxydiglycol, Hydrolyzed Soy Protein, Acetyl Glucosamine, Hydroxyacetophenone, Lactic Acid, Hydrolyzed Opuntia Ficus-Indica Flower Extract, Helianthus Annuus (Sunflower) Seed Oil, Citrus Aurantium Bergamia (Bergamot) Fruit Oil, Citrus Limon (Lemon) Peel Oil, Citrus Aurantium Dulcis (Orange) Peel Oil, Salvia Sclarea (Clary) Oil, Pyrus Malus (Apple) Fruit Extract, Viola Odorata Leaf Extract, Acacia Senegal Gum Extract, Curcuma Longa (Turmeric) Root Extract, Mucor Miehei Extract, Lavandula Spica (Lavender) Flower/Leaf/Stem Extract, Rosmarinus Officinalis (Rosemary) Leaf Oil, Litsea Cubeba Fruit Oil, Camellia Japonica Flower Extract, Glycerin, Mentha Piperita (Peppermint) Oil, Butylene Glycol, Lactobacillus Ferment, Glycogen, Urea, Caprylyl Glycol, Phospholipids, Glucosamine HCl, Xanthan Gum, PEG-40 Hydrogenated Castor Oil, 1,2-Hexanediol, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Citric Acid, Polyacrylate Crosspolymer-6, Acacia Senegal Gum, Sodium Chloride, Sodium Citrate, Disodium EDTA, Sodium Benzoate, Potassium Sorbate, Limonene, Linalool, Citral.
Dermalogica is dedicated to maintaining the accuracy of the ingredient lists on this website. However, because ingredients are subject to change, we cannot guarantee that these lists are complete, up-to-date and/or error-free. For an accurate listing of ingredients in each product, please refer to your product packaging.
Materials: Bottle: Glass, Pump/cap: Mixed material, Carton: Paper
What’s Recyclable: The bottle of this Dermalogica product is fully recyclable. The paper used in this carton is recyclable and comes from FSC certified responsibly managed forests.
How to Recycle: Ensure bottle is as empty as possible and place in recycling bin. Dispose of pump and cap in waste bin. Place carton in its recycling bin.
Recycling is subject to local policies and facilities.
Phyto Nature E² is a regenerating daily leave-on formulated for aging skin. It’s ideal for anyone seeking anti-aging skincare or a skin renewing treatment to address fine lines, wrinkles, dullness, and uneven texture. Recommended for mature or prematurely-aging skin, those experiencing fine lines, wrinkles, and loss of firmness. This leave-on exfoliant supports natural surface renewal for smoother, brighter, and more youthful-looking skin.
Phyto Nature E² features a next-generation Regenerative Exosome Blend with plant-based exosomes that act in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles. Pumpkin Enzyme exfoliates to reveal brighter, smoother skin daily. The Botanical Blend with Phyto Glycogen + Prickly Pear brightens and smooths skin, while Bio-Fermented Acetyl Glucosamine hydrates and provides antioxidant protection.
This anti-aging leave-on accelerates skin regeneration, visibly reduces fine lines and wrinkles, and resurfaces skin to improve brightness, texture, and smoothness. Daily exfoliating enzymes clear away dull surface cells, and regenerative exosomes act in multiple layers to diminish fine lines and wrinkles in as little as two weeks**.
Improves natural skin regeneration by up to 86% versus untreated skin*.
Exosomes are microscopic vesicles that act as cell messengers, enhancing communication between skin cells. In skincare, exosomes help support natural skin regeneration and renewal. Phyto Nature E² uses plant-based exosomes to reinforce cellular renewal and surface resurfacing, making it one of the most advanced exosome skin care products for at-home face treatments.
Exosomes in Phyto Nature E² promote natural skin regeneration and cellular communication, helping improve fine lines, dullness, and uneven texture. Enzymes enhance the benefits with daily exfoliation and help maintain smoother, brighter, and more youthful-looking skin.
Phyto Nature E² has a silky, lightweight texture that absorbs quickly without leaving a greasy residue. Its smooth, nourishing, layerable texture makes it easy to use with other leave-ons or moisturizers while providing gentle, daily skin resurfacing.
Apply Phyto Nature E² to clean skin as the first step after cleansing. Allow it to absorb fully before applying moisturizer or serum. Use twice daily, morning and night, to maximize the benefits of this antiaging, skin-renewing leave-on.
Yes. Phyto Nature E² layers easily with other leave-ons, moisturizers, or treatments. Its lightweight, silky texture supports both exfoliation and skin regeneration while integrating seamlessly into any daily skincare routine.
Phyto Nature E² is formulated for daily exfoliation and anti-aging benefits. Those with sensitive skin should patch test first. The plant-based exosomes and gentle Pumpkin Enzyme work together to support skin renewing and resurfacing without irritation for most users.
Visible improvements in skin smoothness, brightness, and fine lines may appear within two weeks of twice-daily use. Continued use supports long-term skin regeneration, leaving skin softer, firmer, and more radiant over time.
or 4 payments of $39.50 with or
Couldn't load pickup availability
phyto nature e² regenerating daily exosome leave-on treatment
Overall rating: 4.8 / 5 from 585 reviews.
Phyto Nature e² is a lightweight, silky leave-on product that visibly smooths and supports skin regeneration. It is formulated with next-gen exosomes and enzymes to improve natural regeneration by 86%. Customers rave about its ability to make skin look fresher, brighter, and more awake, while also feeling silky and absorbing quickly without residue.
Review topics: [size, absorbs, results, issues, ingredients, irritation, improvement, works, wrinkles, weight, smell, use, quality, fragrance, feels, lines, texture, packaging, value, difference, formula, skin, looks, effect, glow, face, complexion, serum, bottle, residue].
"I’ve been using this product twice a day, for 3 1/2 weeks and it’s absolutely lessened the appearance of the wrinkles on my forehead which is my “problem” area. I took pictures the first night I tried it out and then again last night to compare and feel that there’s a noticeable improvement. My only complaint is that it doesn’t work well with my foundation, it causes pilling. Regardless of that, I’m very pleased with this product and will continue to purchase."
"I've been using Phyto Nature E² for a few weeks and really enjoy the texture and how my skin feels after. It absorbs quickly, layers well under moisturizer, and my skin looks smoother and more refreshed overall."
"Woww. Es un seremos increíble y combina perfecto con el resto de la linea. El tamaño es ideal por su precio. Refrescante. Com muy muy buenos resultados tan solo a pocas semanas de iniciar el uso. Recomiendo mucho no solo este serum, si no, toda la linea. Amo con locura estos productos con resultados reales."
"I've been using Phyto Nature E² Regenerating Daily and I'm really impressed with the results. My skin looks smoother, healthier, and noticeably more youthful. It feels hydrated without being greasy, and my complexion has a nice glow. After using it consistently, I've noticed my skin looks firmer and more refreshed. It's become one of my favorite skincare products, and I would definitely recommend it to anyone looking to improve the overall appearance of their skin."
"This is the best product to date. It is the first thing i put on after I cleanse my face. It blends in to the perfect combination of hydration and glow. After applying this i apply the serum of choice. This product is a game changer."
"I absolutely love this product. I’m 70 years old and have been using it for a month. My skin looks smoother. My pores are tighter. It is definitely making a positive difference."
"I’ve only been using the products for two weeks so I can’t really say that it’s a good thing. I’ve had to cut back to once a day as I have experienced stinging. That being said I have loved all Dermalogica for a long time and I have high hopes. At 74 years old my skin looks great and I give most of the credit to Dermalogica,"
"It’s so lightweight you can layer a serum over top I like to use the morning viramim c serum with it"
"Phyto nature e2 is apart of my daily routine love this product you can layer it with other products"
"Smells amazing, hydrating, and last for a long time! Refreshing"
renew + resurface
hydrates and combats skin aging
exfoliates, smooths, brightens
tightens, tones, sculpts
reduces fine lines and hydrates
treats and prevents body breakouts
Receive a MultiVitamin Power Firm (0.20 oz), Daily Microfoliant (0.14 oz), and Dynamic Skin Recovery SPF50 (0.24 oz) on orders $100+. No code needed. Offer valid while supplies last on qualifying U.S. purchases made on dermalogica.com from 12:00am PST August 16, 2026 through 11:59pm PST August 20, 2026. May not be combined with any coupon, discount or special offer; or applied to previous purchases. Gifts are non-transferable, non-refundable, non-negotiable and cannot be exchanged, returned, or redeemed for cash or merchandise credit. We reserve the right to substitute gift offered with an item of equal or greater value. We reserve the right to modify, cancel and limit any promotion or offer. We reserve the right to make changes to these terms and conditions at any time and for any reason.
Receive a Smart Response Serum (0.17 oz) with the purchase of Smart Eye Density. Limit 1 gift per customer. No code needed. Offer valid while supplies last on qualifying U.S. purchases made on dermalogica.com from 12:00am PST August 3, 2026 through 11:59pm PST September 16, 2026. May not be combined with any coupon, discount or special offer; or applied to previous purchases. Gifts are non-transferable, non-refundable, non-negotiable and cannot be exchanged, returned, or redeemed for cash or merchandise credit. We reserve the right to substitute gift offered with an item of equal or greater value. We reserve the right to modify, cancel and limit any promotion or offer. We reserve the right to make changes to these terms and conditions at any time and for any reason.
Receive free shipping on all orders $20+. No code needed. Offer valid on qualifying continental U.S. purchases made on dermalogica.com from 12:00am PST August 6, 2026 through 11:59pm PST August 27, 2026. Orders outside the continental U.S. will receive free expedited shipping. May not be combined with any coupon, discount or special offer; applied to previous purchases; or redeemed for cash or merchandise credit. We reserve the right to modify, cancel and limit any promotion or offer. We reserve the right to make changes to these terms and conditions at any time and for any reason.
A current list of skin care products eligible for purchase with HSA or FSA funds is available on our designated eligibility page. For comprehensive information regarding HSA/FSA qualifications and permitted card usage, please refer to our HSA/FSA information page. Eligibility requirements may change, and we reserve the right to modify the list of qualifying products at any time without prior notice.
Offer valid on orders $125+. The code to redeem this offer can be found in your sign-up confirmation email. Code must be entered on the cart page to apply. Limit 1 redemption per customer. May not be combined with any coupon, discount or special offer; or applied to previous purchases. Gifts are non-transferable, non-refundable, non-negotiable and cannot be exchanged, returned, or redeemed for cash or merchandise credit. We reserve the right to substitute gift offered with an item of equal or greater value. We reserve the right to modify, cancel and limit any promotion or offer. We reserve the right to make changes to these terms and conditions at any time and for any reason. By clicking SUBSCRIBE, I accept the privacy terms and give my consent to receive Dermalogica marketing e-mails at the e-mail provided. Consent is not a condition of any purchase. Message and data rates may apply. Message frequency varies.
Offer valid for on all subscription orders. Must be signed up to our rewards program at time of order. No code needed.
Select one free travel size product on orders $20+. Must select in cart page. No code needed. Offer valid on qualifying U.S. purchases made on dermalogica.com. Gifts are non-transferable, non-refundable, non-negotiable and cannot be exchanged, returned, or redeemed for cash or merchandise credit. We reserve the right to substitute gift offered with an item of equal or greater value.
