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Daily exosome leave-on visibly smooths and supports skin regeneration. Formulated with next-gen exosomes and enzymes, this lightweight, silky leave-on helps reawaken skin’s natural surface renewal process, improving natural regeneration by 86%.*
Exfoliating enzymes help clear away dull surface cells, revealing smoother, brighter skin. A regenerative exosome blend acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles. In an independent clinical study, fine lines and wrinkles were visibly diminished in 2 weeks.*
*Versus untreated skin. Based on in vitro testing.
**Results at 2 weeks, based on a reduction in visible signs of skin aging in an independent clinical study with 32 subjects, 2 applications/day.
In an 8-week independent clinical study, 32 subjects applied Phyto Nature E² twice daily. In laboratory (in vitro) testing, the formula improved skin's natural regeneration by up to 86% versus untreated skin. Fine lines and wrinkles were visibly diminished in as little as 2 weeks of twice-daily use, and after just one use consumers perceived that their skin looked and acted younger. With continued daily use, skin looks smoother, brighter and more refined.
86%
improved skin's natural regeneration vs untreated skin*
2 weeks
fine lines and wrinkles visibly diminished**
*Versus untreated skin, based on in vitro testing.
**Independent clinical study, 32 subjects, 2 applications/day.
Apply to clean skin. Allow to absorb, then follow with the rest of your skin care routine. Use twice daily.
Key Ingredients:
Pumpkin enzyme: Exfoliates to reveal brighter, smoother skin daily
Regenerative exosome blend: Acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles
Botanical blend with phyto glycogen + prickly pear: Visibly brightens and smooths
Bio-fermented acetyl glucosamine: Hydrates and provides antioxidant protection
Water/Aqua/Eau, Lactobacillus/Pumpkin Ferment Extract, Propanediol, Lactococcus Ferment Lysate, Ethoxydiglycol, Hydrolyzed Soy Protein, Acetyl Glucosamine, Hydroxyacetophenone, Lactic Acid, Hydrolyzed Opuntia Ficus-Indica Flower Extract, Helianthus Annuus (Sunflower) Seed Oil, Citrus Aurantium Bergamia (Bergamot) Fruit Oil, Citrus Limon (Lemon) Peel Oil, Citrus Aurantium Dulcis (Orange) Peel Oil, Salvia Sclarea (Clary) Oil, Pyrus Malus (Apple) Fruit Extract, Viola Odorata Leaf Extract, Acacia Senegal Gum Extract, Curcuma Longa (Turmeric) Root Extract, Mucor Miehei Extract, Lavandula Spica (Lavender) Flower/Leaf/Stem Extract, Rosmarinus Officinalis (Rosemary) Leaf Oil, Litsea Cubeba Fruit Oil, Camellia Japonica Flower Extract, Glycerin, Mentha Piperita (Peppermint) Oil, Butylene Glycol, Lactobacillus Ferment, Glycogen, Urea, Caprylyl Glycol, Phospholipids, Glucosamine HCl, Xanthan Gum, PEG-40 Hydrogenated Castor Oil, 1,2-Hexanediol, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Citric Acid, Polyacrylate Crosspolymer-6, Acacia Senegal Gum, Sodium Chloride, Sodium Citrate, Disodium EDTA, Sodium Benzoate, Potassium Sorbate, Limonene, Linalool, Citral.
Dermalogica is dedicated to maintaining the accuracy of the ingredient lists on this website. However, because ingredients are subject to change, we cannot guarantee that these lists are complete, up-to-date and/or error-free. For an accurate listing of ingredients in each product, please refer to your product packaging.
Materials: Bottle: Glass, Pump/cap: Mixed material, Carton: Paper
What’s Recyclable: The bottle of this Dermalogica product is fully recyclable. The paper used in this carton is recyclable and comes from FSC certified responsibly managed forests.
How to Recycle: Ensure bottle is as empty as possible and place in recycling bin. Dispose of pump and cap in waste bin. Place carton in its recycling bin.
Recycling is subject to local policies and facilities.
awarded and mentioned in 2026
External scientific references supporting the ingredient science referenced on this page (not our clinical testing).
Mature or prematurely-aging skin, and anyone looking to address fine lines and wrinkles, loss of firmness and elasticity, dullness, and uneven texture. Gentle enough for daily use.
A next-generation Regenerative Exosome Blend (plant-based exosomes with Turmeric stem cells and Acacia Senegal); Pumpkin Enzyme; a Botanical Blend of Phyto Glycogen and Prickly Pear; and bio-fermented Acetyl Glucosamine.
Exosomes are microscopic messengers between skin cells that support natural regeneration and renewal; E² uses plant-based exosomes to reinforce cellular communication and surface resurfacing.
E² delivers plant-based exosomes in a daily at-home format. It complements in-clinic treatments (such as Dermalogica PRO's Exo Booster) rather than replacing them. Using it daily helps maintain and extend results between visits.
Yes, plant-derived (Turmeric stem cells and Acacia Senegal), and all current Dermalogica formulas are PETA-certified vegan.
No. E² is developed and tested to stay stable at room temperature. Just keep it out of direct sunlight and excessive heat.
No added synthetic fragrance. Any scent is naturally occurring from the botanical and citrus oils in the formula (which naturally contain limonene, linalool and citral). Patch test first if sensitive.
Apply to clean skin as the first step after cleansing. Allow it to absorb, then follow with the rest of your routine. Use twice daily; in the morning, always finish with SPF.
Yes: apply E² first, then the Phyto Nature Firming Serum; it can also be used with Dynamic Skin Retinol Serum in your PM routine.
E² uses gentle enzymatic exfoliation (Pumpkin Enzyme loosens the bonds between dead surface cells rather than scrubbing). If your skin is sensitive, patch test first and introduce it slowly, adjusting frequency if needed. Avoid the eye area and broken skin.
Visible improvements in smoothness, brightness and fine lines can appear within 2 weeks of twice-daily use (32-subject study). In vitro, E² improved skin's natural regeneration by up to 86% versus untreated skin.
Silky and lightweight. It absorbs quickly without a greasy residue and layers easily under serums or moisturizers.
or 4 payments of $39.50 with or
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phyto nature e² regenerating daily exosome leave-on treatment
Overall rating: 4.793103 / 5 from 609 reviews.
Phyto Nature e² is a lightweight, silky leave-on product that visibly smooths and supports skin regeneration. It is formulated with next-gen exosomes and enzymes to improve natural regeneration by 86%. Customers rave about its ability to make skin look fresher, brighter, and more awake, while also feeling silky and absorbing quickly without residue.
Review topics: [size, irritation, fragrance, issues, absorbs, smell, weight, works, improvement, skin, design, shipping, results, quality, value, difference, feels, benefits, packaging, lines, texture, looks, glow, serum, wrinkles, formula, face, change, complexion, bottle].
"Non-sticky lightweight serum that lives up to the hype. Doesn't break me out, making it easy to commit to using consistently. I've been using this and the smart density eye serum everyday for the last several weeks and it's been a power combo. Hefty bottle is a nice touch considering the price."
"It's rare to find a single product that has such a strong impact on my skin's firmness. I put this to the test on the back of my hands as well, and the crepiness has almost completely smoothed out. Overall, my skin feels brighter, and fine lines are much less noticeable."
"I want to love this product but after using it consistently twice per day I just don't see a difference. I like the way the product feels. It absorbs nicely and smells great but for the price I would like to see at least a tiny difference. I am going to finish this bottle and perhaps my results will improve."
"Recently something changed and my skin became sensitive. I used Dermalogica sensitive products and was ready to move on. I read about the Phyto Nature e2 and decided to try it. I started out using just once a day to make sure it didn’t irritate my skin. I love what it does to my skin’s appearance and how it feels. I don’t really like goopy feeling moisturizers. It’s a great addition to my other Dermalogica products! You won’t be disappointed!"
"I have been really enjoying this product line. Not only have I personally seen a difference in my complexion, but a close friend of mine commented last week saying, “your skin looks amazing!” Such a huge compliment because I have always struggled with acne, scarring, and uneven complexion. I will continue to use this line including serum and moisturizer thanks to the verifiable results!"
"The ads for this product show drastic skin improvement and changes but I haven't seen that. I've used it twice a day for over a month and haven't seen a difference at all. I wish that it wasn't too late to get a refund because this was very expensive."
"I was skeptical when I got this. I'm 70+ and have used Dermalogica products since the mid-1990s, so my skin was already pretty good for my age. But this was a game changer. My sink feels and looks noticeably more vibrant! I've tried a lot of the serums that have been introduced over the years, and this is the best. Its a keeper."
"I’ve been using this product twice a day, for 3 1/2 weeks and it’s absolutely lessened the appearance of the wrinkles on my forehead which is my “problem” area. I took pictures the first night I tried it out and then again last night to compare and feel that there’s a noticeable improvement. My only complaint is that it doesn’t work well with my foundation, it causes pilling. Regardless of that, I’m very pleased with this product and will continue to purchase."
"This is the best treatment skin care I've been using for 14 days and see big changes with my skin and see big changes . I used this after shower first skin care then Incorporate it with other dermatologica skin care . It's pricey but worth the investment as I know it will change my skin in the long haul . best skin care investment I think it's worth it as I'm looking forward for big changes in my skin care best anti-aging skin care treatment."
"I've been using Phyto Nature E² for a few weeks and really enjoy the texture and how my skin feels after. It absorbs quickly, layers well under moisturizer, and my skin looks smoother and more refreshed overall."
renew + resurface
hydrates and combats skin aging
exfoliates, smooths, brightens
tightens, tones, sculpts
reduces fine lines and hydrates
treats and prevents body breakouts
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