3 min read
Papain: the papaya enzyme behind smooth, radiant skin
11/17/2025
What it is:
A proteolytic enzyme from papaya that breaks down keratin proteins in dead skin cells¹,².
What it does:
- Dissolves dead surface cells by hydrolyzing keratin and protein bonds¹,².
- Gently exfoliates without abrasion or strong chemical acids¹.
- Smooths and softens skin texture by lifting away rough surface buildup¹.
- Helps unclog pores by breaking down keratin plugs and excess debris¹.
- Boosts radiance and evens tone by removing dull outer cells¹.
- Improves product absorption by clearing the barrier layer of dead cells¹.
- Provides anti-inflammatory effects that may calm skin¹³.
Safety notes:
- May trigger allergic reactions in those sensitive to papaya or latex because papain can degrade tight-junction proteins and induce inflammation⁵.
- Gentle, but overuse may still irritate the skin; use as directed.
- Avoid use on broken or compromised skin until healed.
Papain is a proteolytic enzyme extracted from papaya that works by breaking down keratin proteins in dead surface cells12. This keratin-dissolving action allows papain to loosen and lift away dull, compacted debris without the friction of scrubs or the intensity of chemical acids, making it an effective yet gentle exfoliant for sensitive skin1. Because papain selectively hydrolyzes protein bonds between dead cells2, it helps smooth rough texture, soften fine lines, and unclog pores by clearing buildup that can contribute to congestion1. Removing this outer layer not only reveals brighter, healthier skin but also improves penetration of other skincare ingredients, allowing actives to absorb more effectively1.
Papain’s enzymatic action delivers additional benefits: by removing pore-clogging keratin plugs, it may help reduce bumps and congestion with regular use1. Its nature-derived exfoliation tends to be kinder to the skin barrier than abrasive scrubs or high-strength acids1, and enzymes like papain have also shown anti-inflammatory activity that may help calm the skin13. In formulations like Dermalogica’s Daily Microfoliant, papain works alongside salicylic acid—which clears inside pores4—and rice bran to provide multi-level exfoliation. While papain is generally well tolerated, individuals with sensitivities to papaya, latex, or related fruits should exercise caution, as papain can degrade tight-junction proteins and trigger inflammation in sensitized or allergic individuals5. With mindful use, papain offers a gentle, nature-powered path to smoother, clearer, more radiant skin.
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